Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour
Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour
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DOI：
10.1111/ejn.12719
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发表时间：
2014-11-01
影响因子：
3.4
通讯作者：
Alberi, Lavinia
中科院分区：
文献类型：
--
作者：
Brai, Emanuele;Marathe, Swananda;Alberi, Lavinia
切迹信号在果蝇和啮齿动物的突触可塑性和学习记忆功能中起着重要作用。在本文中，我们报告了这一特征不仅限于海马网，还涉及嗅球(OB)。啮齿动物的气味识别和嗅觉学习是生存所必需的。NOTCH1在小鼠OB的二尖瓣细胞中表达丰富。这些主神经元对特定的输入气味做出反应，并将信号传递到嗅皮层。嗅觉刺激激活二尖瓣细胞的一个子集，显示Notch活性增加。在Notch1cKOKln小鼠中，二尖瓣细胞中Notch1的缺失会影响神经元对嗅觉刺激的反应程度。此外，与野生型对照相比，Notch1cKOKln小鼠对丙酸的嗅觉厌恶程度降低。这首次表明Notch1参与了嗅觉处理，并可能影响嗅觉行为。
Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory bulb (OB). Odour discrimination and olfactory learning in rodents are essential for survival. Notch1 expression is enriched in mitral cells of the mouse OB. These principal neurons are responsive to specific input odorants and relay the signal to the olfactory cortex. Olfactory stimulation activates a subset of mitral cells, which show an increase in Notch activity. In Notch1cKOKln mice, the loss of Notch1 in mitral cells affects the magnitude of the neuronal response to olfactory stimuli. In addition, Notch1cKOKln mice display reduced olfactory aversion to propionic acid as compared to wildtype controls. This indicates, for the first time, that Notch1 is involved in olfactory processing and may contribute to olfactory behaviour.