Cancer cells display increased migration and deformability in pace with metastatic progression.
Cancer cells display increased migration and deformability in pace with metastatic progression.
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DOI：
10.1096/fj.202000101rr
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发表时间：
2020-07
期刊：
影响因子：
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通讯作者：
Barman I
中科院分区：
文献类型：
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作者：
Liu Z;Lee SJ;Park S;Konstantopoulos K;Glunde K;Chen Y;Barman I
在这项研究中，我们探讨了转移状态与受限迁移能力，变形虫转变和细胞刚度之间的关系。我们比较了来自MDA-MB-231细胞的人乳腺癌细胞的等基因组。观察到肺转移后的细胞具有最快的迁移和最低的刚度，具有显著更高的转变成变形模式的能力。我们的研究结果表明，转移是一个选择性的过程，有利于运动和软细胞。此外，循环肿瘤细胞类似于亲本细胞系而不是肺转移细胞的观察结果表明，在外渗和定殖期间可能选择具有更高变形性和运动性的细胞。
In this study, we explored the relation between metastatic states versus the capacity of confined migration, amoeboid transition and cellular stiffness. We compared across an isogenic panel of human breast cancer cells derived from MDA-MB-231 cells. It was observed that cells after lung metastasis have the fastest migration and lowest stiffness, with a significantly higher capacity to transition into amoeboid mode. Our findings illustrate that metastasis is a selective process favoring motile and softer cells. Moreover, the observation that circulating tumor cells resemble the parental cell line, but not lung-metastatic cells, suggests cells with higher deformability and motility are likely selected during extravasation and colonization.