Differential responsiveness of avian vitellogenin I and vitellogenin II during primary and secondary stimulation with estrogen.
Differential responsiveness of avian vitellogenin I and vitellogenin II during primary and secondary stimulation with estrogen.
复制标题
禽类卵黄蛋白原 I 和卵黄蛋白原 II 在雌激素初次和二次刺激期间的差异反应。
DOI：
10.1016/0006-291x(83)91724-2
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发表时间：
1983
影响因子：
3.1
通讯作者：
Williams,DL
中科院分区：
文献类型：
--
作者：
Wang,SY;Williams,DL
鸟类卵黄蛋白原由VTG I和VTG II两个主要物种组成，它们在结构和免疫学性质上有很大的差异，表明VTG I和VTG II是不同的基因产物。在雌激素刺激下，VTG I在血浆中的蓄积速度比VTG II慢得多。激素处理后第1天，VTG I仅为VTG II的1-3%，但到第5天，VTG I增加到约为VTG II的25%。肝脏卵黄原蛋白合成的测量证实，VTG I的诱导较慢，表达减少。此外，对二次雌激素治疗的遗忘或记忆反应也有进一步差异。一次和二次雌激素处理后VTG I和VTG II的积累和合成的测量表明，VTG I的记忆反应比VTG II发生的程度要大得多，这些差异表明VTG I和VTG II的诱导并不是紧密耦合的。
Avian vitellogenin consists of two major species, VTG I and VTG II, which show major differences in structure and immunological properties suggesting that VTG I and VTG II are distinct gene products. During primary stimulation with estrogen, VTG I was found to accumulate in plasma much more slowly than VTG II. At 1 day after hormone treatment VTG I was only 1–3% of VTG II, but by day 5 VTG I increased to approximately 25% of VTG II. Measurements of hepatic vitellogenin synthesis confirmed the slower induction and reduced expression of VTG I. A further difference was noted in the amnestic or memory response to secondary estrogen treatment. Measurements of VTG I and VTG II accumulation and synthesis after primary and secondary estrogen treatment showed that the memory response occurs to a much greater extent for VTG I than VTG II. These differences indicate that the inductions of VTG I and VTG II are not tightly coupled.