Family History of Eating Disorder and the Broad Autism Phenotype in Autism.
Family History of Eating Disorder and the Broad Autism Phenotype in Autism.
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饮食失调的家族史和自闭症的广泛自闭症表型。
DOI：
10.1002/aur.2378
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Cuccaro,Michael
中科院分区：
文献类型：
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作者：
Barrionuevo,BiancaA;Chowdhury,AneesaR;Lee,JoycelynM;Dueker,NicoleD;Martin,EdenR;Pericak-Vance,MargaretA;Cuccaro,Michael
自闭症特征经常出现在饮食失调（ED）患者中。这种共现现象尚不清楚，但有人推测，自闭症和 ED 都有一些共同的特征（例如僵化）。为了探索自闭症特征和 ED 特征的共现，我们使用 Simons Simplex Collection（SSC；N= 2,623 个家庭）来测试具有 ED 特征史的自闭症患者的一级亲属是否具有更多自闭症特征（通过广泛自闭症表型问卷（BAP-Q）测量）与没有 ED 病史的亲属相比。母亲中具有 ED 特征的个体出现频率为 2.2% (N= 57)，兄弟姐妹中出现 ED 特征的频率 <1%，而父亲中则不存在。我们的分析仅限于母亲。与没有 ED 病史的母亲相比，有 ED 病史的母亲在 BAP-Q 总分和三个 BAP-Q 领域的得分显着更高。更重要的是，当使用 BAP-Q 作为分类工具时，我们发现与没有 ED 病史的母亲相比，有 ED 病史的母亲最有可能落入 BAP-Q 刚性域的临床显着范围内。我们的研究结果表明，自闭症患者母亲的 ED 特征史与自闭症特征的存在相关。这扩展了之前显示自闭症和 ED 之间关系的研究，并扩大了与自闭症患者家庭成员的 BAP 相关的神经精神特征的范围。简单总结使用 Simons Simplex Collection 中的信息，我们测试了与没有饮食失调史的自闭症患者的母亲相比，有饮食失调史的自闭症患者的母亲是否具有更多的自闭症特征（即与自闭症患者相似，但更温和）。两组之间最显着的差异是有饮食失调史的母亲存在僵化。这扩展了先前显示自闭症和饮食失调之间关系的工作，并表明在未来自闭症家庭研究中研究饮食失调的效用。Autism Res2020, 13: 1573–1581。 © 2020 国际自闭症研究协会，Wiley periodicals, Inc.
Autism features occur frequently among individuals with eating disorders (ED). This co‐occurrence is not well understood but there is speculation that select traits (e.g., rigidity) are common to both autism and ED. To explore the co‐occurrence of autistic traits and ED features, we used the Simons Simplex Collection (SSC;N= 2,623 families) to test whether first‐degree relatives of individuals with autism with a history of ED features had more autism traits, as measured by the Broad Autism Phenotype Questionnaire (BAP‐Q), compared to relatives with no history of ED. The frequency of individuals with ED features was 2.2% (N= 57) among mothers, <1% in siblings, and not present in fathers. We restricted our analyses to mothers. Compared to mothers with no history of ED, those with a history of ED had significantly higher scores on the BAP‐Q Total Score and each of the three BAP‐Q domains. More importantly, when the BAP‐Q was used as a classification tool, we found that when compared to mothers with no history of ED, those with a history of ED were most likely to fall into the clinically significant range on the BAP‐Q Rigid domain. Our results suggest that a history of ED features among mothers of individuals with autism is associated with the presence of autistic traits. This extends previous work showing a relationship between autism and ED and expands the range of neuropsychiatric traits that have relevance to the BAP among family members of individuals with autism.Lay SummaryUsing information from the Simons Simplex Collection we tested whether mothers of individuals with autism with a history of eating disorder had more autism traits (i.e., similar to those in autism but milder) compared to mothers with no history of eating disorder. The most striking difference between the groups was the presence of rigidity in mothers with a history of eating disorder. This extends previous work showing a relationship between autism and eating disorders and suggests the utility of studying eating disorders in future family studies of autism.Autism Res2020, 13: 1573–1581. © 2020 International Society for Autism Research, Wiley Periodicals, Inc.