Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial.
Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial.
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DOI：
10.1089/acm.2008.0402
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Wahner-Roedler DL
中科院分区：
文献类型：
--
作者：
Thompson MA;Bauer BA;Loehrer LL;Cha SS;Mandrekar JN;Sood A;Wahner-Roedler DL
确定外源性S-腺苷-L-甲硫氨酸（蛋氨酸）（一种常用的营养补充剂）是否会增加健康受试者血浆同型半胱氨酸（Hcy）水平（一种潜在的心血管风险因素）。双盲、安慰剂对照、随机临床试验。马约诊所，罗切斯特，明尼苏达州。52名健康志愿者。受试者接受安慰剂或二甲双胍（每天800 mg）治疗4周。在给药前和给药后测量Hcy水平。主要结果指标是Hcy水平的变化。次要结局指标包括中期Hcy测定（2周时）和高敏C反应蛋白（hsCRP）、脂质和丙氨酸氨基转移酶水平的变化。两组间Hcy无统计学显著性变化。同样，在第2周或第4周，未观察到Hcy或hsCRP水平变化的统计学显著差异。与安慰剂组相比，在第2周时丙氨酸氨基转移酶有一个小的但具有统计学意义的增加（p < 0.04），而在THEMET组中总胆固醇有一个具有统计学意义的降低（p < 0.04）。每日剂量800 mg的蛋氨酸持续4周似乎不会显着影响血液中的Hcy水平。
To determine if exogenous S-adenosyl-l-methionine (AdoMet), a commonly used nutritional supplement, increases the level of plasma homocysteine (Hcy), a potential cardiovascular risk factor, in healthy human subjects. Double-blind, placebo-controlled, randomized clinical trial. Mayo Clinic, Rochester, Minnesota. Fifty-two (52) healthy human volunteers. Subjects received placebo or AdoMet (800mg per day) for 4 weeks. Hcy levels were measured before and after administration of AdoMet or placebo. The primary outcome measure was change in Hcy level. Secondary outcome measures included an interim Hcy determination (at 2 weeks) and changes in levels of high-sensitivity C-reactive protein (hsCRP), lipids, and alanine aminotransferase. There was no statistically significant change in Hcy between groups. Similarly, no statistically significant differences in change in Hcy or hsCRP levels were observed at 2 or 4 weeks. There was a small but statistically significant increase (p < 0.04) in alanine aminotransferase at week 2 and a statistically significant decrease (p < 0.04) in total cholesterol in the AdoMet group compared with the placebo group. AdoMet at a daily dose of 800mg for 4 weeks does not appear to significantly affect Hcy levels in the blood.
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影响因子：
158.5
作者：
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