Electrocorticographic Control of a Prosthetic Arm in Paralyzed Patients
Electrocorticographic Control of a Prosthetic Arm in Paralyzed Patients
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DOI：
10.1002/ana.22613
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发表时间：
2012-03-01
影响因子：
11.2
通讯作者：
Yoshimine, Toshiki
中科院分区：
文献类型：
--
作者：
Yanagisawa, Takufumi;Hirata, Masayuki;Yoshimine, Toshiki
目的：脑皮质电图（ECoG）控制的假肢可以帮助瘫痪患者恢复运动功能。尽管ECoG在人类志愿者中显示出令人鼓舞的结果，但长期瘫痪患者的ECoG信号是否能提供足够的运动信息尚不清楚，如果能，是否能用于控制假肢。方法：记录12例患者进行或试图进行3 ~ 5个简单手、肘动作时的感觉运动皮层的脑电图信号。周围神经系统病变或截肢导致感觉运动功能严重受损3例，中枢神经系统病变保留皮层导致感觉运动功能中度受损4例，正常5例。对患者脑电图信号进行时频分析和解码分析。结果：所有患者运动时脑电图信号的高γ功率（80-150Hz）对运动类型有明显的响应，为区分不同的运动类型提供了最好的信息。尽管在运动功能严重受损的患者中，不同运动类型的ECoG功率调节之间的差异明显较小，但所有患者的分类表现都明显优于机会。在受损患者中，皮层表征倾向于相互重叠。最后，利用实时分类方法，1例中度损伤患者和3例非瘫痪患者成功控制了义肢。解释：ECoG信号对假肢手臂的控制很有用，可能为麻痹患者提供临床上可行的运动恢复，但没有感觉运动皮层损伤。神经网络学报2012；71:353 - 361
Objective: Paralyzed patients may benefit from restoration of movement afforded by prosthetics controlled by electrocorticography (ECoG). Although ECoG shows promising results in human volunteers, it is unclear whether ECoG signals recorded from chronically paralyzed patients provide sufficient motor information, and if they do, whether they can be applied to control a prosthetic.Methods: We recorded ECoG signals from sensorimotor cortices of 12 patients while they executed or attempted to execute 3 to 5 simple hand and elbow movements. Sensorimotor function was severely impaired in 3 patients due to peripheral nervous system lesion or amputation, moderately impaired due to central nervous system lesions sparing the cortex in 4 patients, and normal in 5 patients. Time frequency and decoding analyses were performed with the patients' ECoG signals.Results: In all patients, the high gamma power (80-150Hz) of the ECoG signals during movements was clearly responsive to movement types and provided the best information for classifying different movement types. The classification performance was significantly better than chance in all patients, although differences between ECoG power modulations during different movement types were significantly less in patients with severely impaired motor function. In the impaired patients, cortical representations tended to overlap each other. Finally, using the classification method in real time, a moderately impaired patient and 3 nonparalyzed patients successfully controlled a prosthetic arm.Interpretation: ECoG signals appear useful for prosthetic arm control and may provide clinically feasible motor restoration for patients with paralysis but no injury of the sensorimotor cortex. ANN NEUROL 2012;71:353-361