Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C
Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C
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DOI：
10.1007/s535-002-8130-z
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发表时间：
2002-01-01
影响因子：
6.3
通讯作者：
Kumada, H
中科院分区：
文献类型：
--
作者：
Kobayashi, M;Arase, Y;Kumada, H
背景本研究的目的是根据B肝炎病毒（HBV）的基因型，在东京都慢性肝病和B肝炎表面抗原（HBsAg）阳性患者的首次医院咨询的临床特征进行评估。方法.受试者包括1077例HBeAg阳性的慢性肝病患者。HBV基因型通过酶联免疫吸附试验（ELISA）确定，使用PreS2单克隆抗体，这是特异性的HBV基因型在PreS2区域。结果基因型A的患者比例为21a（20例患者），基因型B 9%（101例患者），基因型C 88%（945例患者），而11例患者（1.0%）有其他基因型，包括基因型D和F各2例（0.2%），7例（0.6%）无法分型。与基因型B的患者相比，基因型A的患者在第一次咨询时更容易出现B型肝炎包膜抗原（HBeAg）阳性（P = 0.049）。基因型B的患者与基因型A（P = 0.049）和基因型C（P = 0.001）的患者相比，首次就诊时HBeAg阴性的可能性更大，出现轻微肝纤维化的可能性更大（P = 0.003），发生肝硬化的可能性最小（P = 0.005）。C基因型患者可能是HBeAg阳性（P = 0.001），并有HBV感染的阳性家族史（P = 0.0002）。结论.东京大都市HBV感染患者的临床特征因HBV基因型而异。
Background The aim of the present study was to evaluate the clinical characteristics at first hospital consultation, according to the genotype of hepatitis B virus (HBV), in patients with chronic liver diseases and positivity for hepatitis B surface antigen (HBsAg) in metropolitan Tokyo. Methods. The subjects consisted of 1077 patients with chronic liver diseases who were HBsAg-positive. HBV genotype was determined by an enzyme-linked immunosorbent assay (ELISA), using PreS2 monoclonal antibody, which is specific for HBV genotypes in the PreS2 region. Results. The proportion of patients with genotype A was 2 la (20 patients), genotype, B 9% (101 patients), and genotype C, 88% (945 patients), while 11 patients (1.0%) had other genotypes, including 2 (0.2%) each with genotypes D and F, and 7 (0.6%) that were untypeable. Patients with genotype A were significantly (P = 0.049) more likely to be positive for Hepatitis B envelope antigen (HBeAg) at the first consultation compared with those with genotype B. Patients with genotype B were significantly more likely to be HBeAg-negative at the first consultation compared with those with genotype A (P = 0.049) and genotype C (P = 0.001), significantly more likely to show minimal hepatic fibrosis (P = 0.003), and least likely to develop liver cirrhosis (P = 0.005). Patients with genotype C were likely to be HBeAg-positive (P = 0.001) and to have a positive family history of HBV infection (P = 0.0002). Conclusions. The clinical features of patients with HBV infection in metropolitan Tokyo varied depending on the HBV genotype.