Crotofolane-Type Diterpenoids, Crotocascarins L-Q, and a Rearranged Crotofolane-Type Diterpenoid, Neocrotocascarin, from the Stems of Croton cascarilloides
Crotofolane-Type Diterpenoids, Crotocascarins L-Q, and a Rearranged Crotofolane-Type Diterpenoid, Neocrotocascarin, from the Stems of Croton cascarilloides
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DOI：
10.1248/cpb.c16-00500
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发表时间：
2016-10-01
影响因子：
1.7
通讯作者：
Yamaguchi, Kentaro
中科院分区：
文献类型：
--
作者：
Kawakami, Susumu;Inagaki, Masanori;Yamaguchi, Kentaro
从巴豆茎中进一步分离得到巴豆叶烷型二萜化合物L-Q(1-6)和重排后的化合物(7)，命名为新胡萝卜苷。它们的结构通过波谱证据得到确证。并通过X-射线晶体分析确定了新胡萝卜素0(4)和新胡萝卜素(7)的结构。结果发现，新胡萝卜素(7)具有新的碳骨架。文中还讨论了新胡萝卜素(7)的形成机理。
From the stems of Croton cascarilloides, further crotofolane-type diterpenoids, named crotocascarins L-Q (1-6), and a rearranged one (7), named neocrotocascarin were isolated. Their structures were elucidated from spectroscopic evidence. Also, the structures of crotocascarin 0 (4) and neocrotocascarin (7) were determined by X-ray crystallographic analyses. As a result, neocrotocascarin (7) was found to possess a new carbon framework. A plausible mechanism for the formation of neocrotocascarin (7) is also discussed.