Generation and functional confirmation of a conditional null PPARγ allele in mice
Generation and functional confirmation of a conditional null PPARγ allele in mice
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DOI：
10.1002/gene.10042
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发表时间：
2002-02-01
期刊：
影响因子：
1.5
通讯作者：
Magnuson, MA
中科院分区：
文献类型：
--
作者：
Jones, JR;Shelton, KD;Magnuson, MA
过氧化物酶体增殖激活受体γ (PPARγ)是核受体超家族的一员（Dreyer et al., 1992）。该转录因子可通过结合15-deoxy-Δ12, 14jpro -tagandin J2或一类合成配体噻唑adinediones激活（Forman et al., 1995; kleiewer et al., 1995; Lehman et al., 1995）。PPARγ在许多组织中表达，但在白色和棕色脂肪组织、巨噬细胞和结肠中浓度最高。该受体已成为众多研究的焦点，这些研究表明它与多种生物过程有关，包括脂肪形成、葡萄糖稳态、动脉粥样硬化、炎症和癌症(Braissant等人，1996；
Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the nuclear receptor super family (Dreyer et al., 1992). This transcription factor is activated either by the binding of 15-deoxy-Δ12, 14Jpros-tagandin J2 or by thiazoladinediones, a class of synthetic ligands (Forman et al., 1995; Kliewer et al., 1995; Lehman et al., 1995). PPARγ is expressed in many tissues but is found in the highest concentration in white and brown adipose tissue, macrophages, and the colon. This receptor has been the focus of numerous studies that have implicated it in multiple biological processes including adipogenesis, glucose homeostasis, atherogenesis, inflammation, and cancer (Braissant et al., 1996;