ORegAnno: an open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation
ORegAnno: an open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation
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DOI：
10.1093/bioinformatics/btk027
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发表时间：
2006-03-01
期刊：
影响因子：
5.8
通讯作者：
Jones, SJM
中科院分区：
文献类型：
--
作者：
Montgomery, SB;Griffith, OL;Jones, SJM
动机：我们对基因调控的理解目前受到我们集体合成和编录科学文献中存储的转录调控元件的能力的限制。在过去的十年中，随着生物验证调控序列的积累加速，这项任务变得越来越具有挑战性。为了应对这一挑战，需要新的基于社区的调控元件注释方法。摘要：在这里，我们提出开放调控注释（ORegAnno）数据库，作为文献策划的调控区域、转录因子结合位点和调控突变（多态性和单倍型）的动态集合。 ORegAnno 旨在管理全球用户新注释的提交、索引和验证。向 ORegAnno 提交的内容将立即交叉引用到 EnsEMBL、dbSNP、Entrez Gene、NCBI 分类数据库和 PubMed（如果适用）。
Motivation: Our understanding of gene regulation is currently limited by our ability to collectively synthesize and catalogue transcriptional regulatory elements stored in scientific literature. Over the past decade, this task has become increasingly challenging as the accrual of biologically validated regulatory sequences has accelerated. To meet this challenge, novel community-based approaches to regulatory element annotation are required.Summary: Here, we present the Open Regulatory Annotation (ORegAnno) database as a dynamic collection of literature-curated regulatory regions, transcription factor binding sites and regulatory mutations (polymorphisms and haplotypes). ORegAnno has been designed to manage the submission, indexing and validation of new annotations from users worldwide. Submissions to ORegAnno are immediately cross-referenced to EnsEMBL, dbSNP, Entrez Gene, the NCBI Taxonomy database and PubMed, where appropriate.