Mitochondrial Haplogroups Modify the Effect of Diabetes Duration and HbA1c on Proliferative Diabetic Retinopathy Risk in Patients With Type 2 Diabetes.
Mitochondrial Haplogroups Modify the Effect of Diabetes Duration and HbA1c on Proliferative Diabetic Retinopathy Risk in Patients With Type 2 Diabetes.
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线粒体单倍群改变糖尿病持续时间和 HbA1c 对 2 型糖尿病患者增殖性糖尿病视网膜病变风险的影响。
DOI：
10.1167/iovs.17-22804
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发表时间：
2017
影响因子：
4.4
通讯作者：
Bran
中科院分区：
文献类型：
--
作者：
Mitchell,SabrinaL;Neininger,AbigailC;Bruce,CarleighN;Chocron,IsaacM;Bregman,JanaA;Estopinal,ChristopherB;Muhammad,Ayesha;Umfress,AllisonC;Jarrell,KelliL;Warden,Cassandra;Harlow,PaulaA;Wellons,Melissa;Samuels,DavidC;Bran
目的：我们之前证明了欧洲线粒体单倍群与增殖性糖尿病视网膜病变（PDR）之间的关联。本研究的目的是确定这些单倍群与糖尿病病程和高血糖（糖尿病视网膜病变 (DR) 的两个主要危险因素）之间的关系如何影响 PDR 患病率。 方法：我们的人群包括患有 DR 的 2 型糖尿病患者 (n= 377) 和不患有 DR 的患者 (n= 480)。 Kruskal-Wallis 检验用于比较线粒体单倍群中的糖尿病持续时间和 A1c 血红蛋白 (HbA 1c)。在欧洲线粒体单倍群的背景下，进行逻辑回归研究糖尿病病程和 HbA 1c 作为 PDR 的危险因素。结果：线粒体单倍群之间的糖尿病病程和 HbA 1c 均无差异。在单倍群 H 的 DR 患者中，较长的糖尿病病程和 HbA 1c 升高是 PDR 的显着危险因素（分别为 P= 0.0001 和 P= 0.011）。在英国单倍群的 DR 患者中，糖尿病病程和 HbA 1c 都不是 PDR 的显着危险因素。结论：欧洲线粒体单倍群改变了糖尿病病程和 HbA 1c 对 2 型糖尿病患者 PDR 风险的影响。在我们的患者群体中，较长的糖尿病病程和较高的 HbA 1c 会增加单倍群 H 患者的 PDR 风险，但不会影响单倍群 UK 患者的 PDR 风险。这种关系之前尚未得到证实，并且可以部分解释为什么一些非增殖性 DR 患者会发展为 PDR，而其他患者则不会，尽管糖尿病病程和血糖控制相似。
Purpose: We previously demonstrated an association between European mitochondrial haplogroups and proliferative diabetic retinopathy (PDR). The purpose of this study was to determine how the relationship between these haplogroups and both diabetes duration and hyperglycemia, two major risk factors for diabetic retinopathy (DR), affect PDR prevalence.Methods: Our population consisted of patients with type 2 diabetes with (n= 377) and without (n= 480) DR. A Kruskal-Wallis test was used to compare diabetes duration and hemoglobin A1c (HbA 1c) among mitochondrial haplogroups. Logistic regressions were performed to investigate diabetes duration and HbA 1c as risk factors for PDR in the context of European mitochondrial haplogroups.Results: Neither diabetes duration nor HbA 1c differed among mitochondrial haplogroups. Among DR patients from haplogroup H, longer diabetes duration and increasing HbA 1c were significant risk factors for PDR (P= 0.0001 and P= 0.011, respectively). Neither diabetes duration nor HbA 1c was a significant risk factor for PDR in DR patients from haplogroup UK.Conclusions: European mitochondrial haplogroups modify the effects of diabetes duration and HbA 1c on PDR risk in patients with type 2 diabetes. In our patient population, longer diabetes duration and higher HbA 1c increased PDR risk in patients from haplogroup H, but did not affect PDR risk in patients from haplogroup UK. This relationship has not been previously demonstrated and may explain, in part, why some patients with nonproliferative DR develop PDR and others do not, despite similar diabetes duration and glycemic control.