Persistent amenorrhoea in weight-recovered anorexics: psychological and biological aspects
Persistent amenorrhoea in weight-recovered anorexics: psychological and biological aspects
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DOI：
10.1016/s0165-1781(03)00074-x
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发表时间：
2003-06-15
影响因子：
11.3
通讯作者：
Maj, M
中科院分区：
文献类型：
--
作者：
Brambilla, F;Monteleone, P;Maj, M
研究人员对 22 名既往患有神经性厌食症 (AN) 的女性进行了人口统计学、精神病理学和激素参数的研究，这些女性目前已经康复，处于稳定的营养正常化状态，持续 3 个月至 2 年，但持续闭经，并研究了 20 名心理生理健康、年龄和性别匹配、月经正常的对照组。患者和对照组的体重指数（BMI）值没有差异。通过饮食失调量表 1、爱丁堡暴食症调查测试、耶鲁-布朗-康奈尔饮食失调量表和三维人格问卷评定量表监测的心理检查显示，AN 的一些精神病理症状持续存在。激素检查包括促卵泡激素、促黄体激素、雌激素 (E)、黄体酮、促甲状腺激素、FT3、FT4（免疫放射测定）、瘦素 (LEP)（酶联免疫吸附测定）和 24 小时尿游离皮质醇（免疫放射测定）的基础血浆浓度。患者和对照组的激素值相同，但 E 和 LEP 水平除外，患者的 E 和 LEP 水平显着低于对照组。两种激素的浓度与患者的BMI不相关，但LEP值与现时BMI与厌食前BMI的差值呈负相关。这两种激素的值与 AN 典型的一些精神病理方面呈负相关，特别是与高“身体不满意”、“无效”和“人际不信任”以及低“内感受意识”相关。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Demographic, psychopathological and hormonal parameters of 22 women with previous anorexia nervosa (AN) presently recovered, in a state of stabilized nutritional normalization for 3 months to 2 years but with persistent amenorrhoea, and of 20 psychophysically healthy age- and sex-matched normally menstruating controls were studied. Body mass index (BMI) values did not differ in patients and controls. Psychological examination, monitored by Eating Disorder Inventory 1, Bulimic Investigation Test Edinburgh, Yale-Brown-Cornell Eating Disorder Scale, and Tridimensional Personality Questionnaire rating scales', showed the persistence of some of the psychopathological symptoms of AN. Hormonal examinations included basal plasma concentrations of follicle stimulating hormone, luteotropic hormone, estrogens (E), progesterone, thyrotropic hormone, FT3, FT4 (immunoradiometric assays), leptin (LEP) (enzymatic-linked-immunosorbent assay) and 24 h urinary free cortisol (immunoradiometric assay). Hormone values were the same in patients and controls, except for E and LEP levels, which were significantly lower in patients than in controls. The concentrations of the two hormones were not correlated with the BMI of the patients, but LEP values were correlated negatively with the difference between the present BMI and the preanorexic one. The values of both hormones correlated negatively with some of the psychopathological aspects typical of AN, in particular with high 'body dissatisfaction', 'ineffectiveness', and 'interpersonal distrust' and with low 'interoceptive awareness'. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.