EFFECT OF CHRONIC INSULIN ADMINISTRATION ON FOOD-INTAKE AND BODY-WEIGHT IN RATS
EFFECT OF CHRONIC INSULIN ADMINISTRATION ON FOOD-INTAKE AND BODY-WEIGHT IN RATS
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DOI：
10.1016/0031-9384(91)90021-f
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发表时间：
1991-10-01
影响因子：
2.9
通讯作者：
CASTONGUAY, TW
中科院分区：
文献类型：
--
作者：
DESTEFANO, MB;STERN, JS;CASTONGUAY, TW
长期给大鼠注射胰岛素，以确定其对每日食物摄入量和体重变化的影响。动物通过14天渗透性微型泵接受剂量为0.0、0.5、1.0、3.0和5.0 IU/天的常规胰岛素治疗，分别用（+GLU）或不加谷氨酸（-GLU）治疗。先前的研究表明，谷氨酸可以阻止胰岛素在微型泵中的聚集，从而提供更稳定的流速。每天测量食物摄入量和体重。除了最高剂量外，慢性胰岛素治疗对任何剂量的胰岛素都没有促进作用。接受5.0 IU/天胰岛素+GLU治疗的动物在治疗的第4天经历了短暂的嗜食和体重增加，随后食物摄入量和体重受到抑制。在接受胰岛素-GLU治疗的动物中，效果减弱。第14天，所有剂量的血浆胰岛素浓度相似，表明在胰岛素降解或内源性胰岛素产生方面发生了补偿。结果表明，谷氨酸治疗可增强渗透小泵慢性胰岛素给药的效果。
Insulin was chronically administered to rats to determine its effect on the daily changes in food intake and body weight. Animals received regular insulin via 14-day osmotic minipumps in doses of 0.0, 0.5, 1.0, 3.0, and 5.0 IU/day treated either with (+GLU) or without glutamic acid (-GLU). Previous studies have shown that glutamic acid prevents insulin aggregation in the minipumps to provide a more stable flow rate. Food intake and body weights were measured each day of treatment. Chronic insulin treatment was ineffective in promoting changes in animals receiving any dose of insulin except the highest dose. Animals receiving 5.0 IU/day insulin +GLU experienced a transient hyperphagia and weight gain followed by a suppression in food intake and body weight by Day 4 of treatment. Effects were attenuated in animals receiving insulin -GLU. Plasma insulin concentrations on Day 14 were similar for all doses, suggesting a compensation took place either in insulin degradation or endogenous insulin production. Results indicate that glutamic acid treatment enhances the effects of chronic insulin administration via osmotic minipumps.