Adverse effects of growth in the glomerular microcirculation.
Adverse effects of growth in the glomerular microcirculation.
复制标题
肾小球微循环生长的不利影响。
DOI：
10.1152/ajprenal.1990.258.5.f1409
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hostetter,TH
中科院分区：
文献类型：
--
作者：
Daniels,BS;Hostetter,TH
代偿性肾脏和肾小球肥大伴随着许多功能和结构变化，这些变化与功能性肾脏质量减少有关。在肾次全切除大鼠中，从缺乏到2.3%Na+（比大鼠每日最低需求量高38倍）的膳食钠补充水平增加与蛋白尿和肾脏大小的进行性升高相关，而动脉压无任何显著变化。为了进一步确定这些关系，对两种中等钠摄入水平的大鼠组进行了详细研究。单肾单位滤过率和肾小球毛细血管压力在肾大部切除大鼠喂养0.06和0.46%Na+饮食相似。高碘酸-希夫染色肾小球系膜病变的体积分数和绝对体积均大于0.46%Na+组。0.46%Na+组肾小球体积和平均肾小球毛细血管半径较大。拉普拉斯定律预测的肾小球张力增加可能是代偿性生长和/或肾小球高血压导致肾小球损伤的最终共同途径。
Compensatory renal and glomerular hypertrophy accompanies the many functional and structural changes associated with a reduction in functional renal mass. Increased levels of dietary sodium supplementation ranging from deficient to 2.3% Na+ (38-fold above the minimal daily requirement for the rat) in rats with subtotal nephrectomy were associated with a progressive rise in proteinuria and renal size without any significant change in arterial pressure. To further define these relationships, groups of rats on two intermediate levels of sodium intake were studied in detail. Single-nephron filtration rate and glomerular capillary pressure were similar in subtotally nephrectomized rats fed the 0.06 and 0.46% Na+ diets. Both the volume fraction and absolute volume of periodic acid-Schiff staining mesangial lesions in the glomerulus were greater in the 0.46% Na+ group. Glomerular volume and the mean glomerular capillary radius was larger in the 0.46% Na+ group. Increased glomerular tension, as predicted by the Laplace law, may represent a final common pathway by which compensatory growth and/or glomerular hypertension result in glomerular injury.