Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane.
Selectively fluorinated cyclohexane building blocks: Derivatives of carbonylated all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane.
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DOI：
10.3762/bjoc.11.287
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发表时间：
2015
影响因子：
2.7
通讯作者：
O'Hagan D
中科院分区：
文献类型：
--
作者：
Ayoup MS;Cordes DB;Slawin AM;O'Hagan D
钯催化的羰基化反应使用的Meta-和对-碘衍生物的全-顺式-3-苯基-1，2，4，5-四氟环己烷（4）被说明为各种官能团相互转化的起点。所得的苯甲醛和苯甲酸提供了新的结构单元，用于进一步衍生化，并有利于将表面极化的全顺式-1，2，4，5-四氟环己烷基序掺入更先进的分子支架中。
Palladium catalysed carbonylation reactions using the meta- and para-iodo derivatives of all-cis-3-phenyl-1,2,4,5-tetrafluorocyclohexane (4) are illustrated as the start point for a variety of functional group interconversions. The resultant benzaldehyde and benzoic acids offer novel building blocks for further derivatisation and facilitate the incorporation of the facially polarised all-cis-1,2,4,5-tetrafluorocyclohexane motif into more advanced molecular scaffolds.