A Novel Endoscopic Clipping Device for Closing Gastrointestinal Perforation

A Novel Endoscopic Clipping Device for Closing Gastrointestinal Perforation
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一种新型内窥镜闭合胃肠穿孔夹闭装置

DOI:
10.1115/1.4033784
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发表时间:
2016-09
影响因子:
0.9
通讯作者:
Zhou Yu
Zhou Yu
中科院分区:
工程技术4区
文献类型:
--
作者:
Song Chengli;Ge Shuchen;Li Mingyang;Yan Shiju;Zhou Yu

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1 背景过去40年来,内夹的临床应用已从胃肠道(GI)止血扩展到支架/导管的固定以及其他干预措施。此外,内夹闭合现已被内窥镜医师广泛接受,并被认为是胃肠道穿孔的标准治疗方法,因为其方便、避免手术治疗和可靠的结果[1-6]。市场上有几种单发设备:Quick-Clip2、QuickClip Pro、Resolution Clip、Instinct Clip 和 Overthe-Scope Clip (OTSC)[7-9]。尽管多重发射装置Clipmaster3可以一次部署三个弹夹,但该装置的功效尚未得到证实,因为没有临床或实验报告[10]。一般来说,穿孔的尺寸小于1.5厘米,仅用五个弹夹就无法闭合(OTSC除外,其尺寸较大,需要额外的程序来去除弹夹)。然而,大多数商业设备/产品都是单发的,因此它们不适合连续部署,这在交换剪辑时非常耗时。在这项工作中,设计了一种用于胃肠道闭合的新型内窥镜多重点火夹闭装置,并进行了离体测试以评估其可行性。
1 BackgroundOver the past 40 years, clinical use of endoclips has been extended from gastrointestinal (GI) hemostasis to the fixation of stents/catheters and for other interventions. Moreover, closure by endoclips are now broadly accepted by endoscopists and considered as the standard treatment of GI perforations for its convenience, avoiding surgical treatment, and reliable outcome [1–6]. Several single-firing devices are available in market: Quick-Clip2, QuickClip Pro, Resolution Clip, Instinct Clip, and Overthe-Scope Clip (OTSC)[7–9]. Although the multifiring device Clipmaster3 can deploy three clips at a time, the efficacy of this device is not proved as there is no clinical or experimental report [10].In general, the size of perforation is less than 1.5 cm and it is too big to be closed with only five clips (expect for OTSC, which has a larger size and will need additional procedure for clip removal). However, most of the commercial devices/products are single-firing so that they are not ideal for continuous deployment, which is time-consuming in exchanging clips. In this work, a novel endoscopic multifiring clipping device for GI closure is designed, and ex vivo testing has been performed to evaluate its feasibility.
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