Estimation of the partial volume effect in MRI
Estimation of the partial volume effect in MRI
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DOI：
10.1016/s1361-8415(02)00061-0
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发表时间：
2002-12-01
影响因子：
10.9
通讯作者：
Brady, M
中科院分区：
文献类型：
--
作者：
Gonzalez Ballester, MA;Zisserman, AP;Brady, M
当一个体素中出现一种以上的组织类型时，部分体积效应（PVE）就会出现在体积图像中。在这种情况下，体素强度不仅取决于成像序列和组织特性，而且还取决于体素中存在的每种组织类型的比例。我们在以前的工作中已经证明，通过建立基于二进制体素的分割来忽略这种效应会在定量测量中引入显著的误差，例如对大脑结构体积的估计。在本文中，我们提供了一个统计估计框架来量化PVE和传播基于体素的估计，以计算全球的幅度，如体积，与相关的不确定性估计。对地面真实合成图像和MRI体模进行验证，并报告了临床研究。结果表明，该方法允许强大的形态学研究，并提供分辨率无法达到的日期。(C)2002 Elsevier Science B.V.保留所有权利。
The partial volume effect (PVE) arises in volumetric images when more than one tissue type occurs in a voxel. In such cases, the voxel intensity depends not only on the imaging sequence and tissue properties, but also on the proportions of each tissue type present in the voxel. We have demonstrated in previous work that ignoring this effect by establishing binary voxel-based segmentations introduces significant errors in quantitative measurements, such as estimations of the volumes of brain structures. In this paper, we provide a statistical estimation framework to quantify PVE and to propagate voxel-based estimates in order to compute global magnitudes, such as volume, with associated estimates of uncertainty. Validation is performed on ground truth synthetic images and MRI phantoms, and a clinical study is reported. Results show that the method allows for robust morphometric studies and provides resolution unattainable to date.(C) 2002 Elsevier Science B.V. All rights reserved.