More than one route to render tumors resistant to cGAS/STING activation.

More than one route to render tumors resistant to cGAS/STING activation.
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使肿瘤抵抗 cGAS/STING 激活的途径不止一种。

DOI:
10.1016/j.tips.2022.11.002
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发表时间:
2023
影响因子:
13.8
通讯作者:
Wang,Yubao
Wang,Yubao
中科院分区:
医学1区
文献类型:
--
作者:
Manokaran,Cherubin;Roberts,ThomasM;Wang,Yubao

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干扰素基因刺激因子(stimulator of interferon genes,STING)的激活作为一种新的肿瘤治疗策略具有相当大的潜力,但临床效果并不令人鼓舞。Hong等人和Li等人最近的研究解释了为什么STING激动剂通常不能使人类肿瘤消退,并提出了克服STING激活的促肿瘤作用的组合策略。
STING (stimulator of interferon genes) activation has considerable potential as a new strategy for cancer therapy, but clinical results have not been encouraging. Recent studies by Hong et al. and Li et al. explain why STING agonists often fail to regress human tumors and propose combinatorial strategies to overcome the protumor effects of STING activation.
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