Interactions between epithelial cells and T lymphocytes: role of adhesion molecules.
Interactions between epithelial cells and T lymphocytes: role of adhesion molecules.
复制标题
上皮细胞和 T 淋巴细胞之间的相互作用：粘附分子的作用。
DOI：
10.1002/jlb.48.4.367
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发表时间：
1990
影响因子：
5.5
通讯作者：
Singer,KH
中科院分区：
文献类型：
--
作者：
Singer,KH
细胞间相互作用对于正常的T细胞发育和功能至关重要。已经确定了许多在T细胞与其他细胞类型相互作用中重要的粘附分子。本文综述了CD 2/LFA-3和LFA-1/ICAM-1两种粘附途径在T细胞与胸腺和皮肤上皮细胞相互作用中的作用。虽然胸腺上皮-T细胞相互作用由LFA-1/ICAM-1途径和CD 2/LFA-3途径介导，但表皮-T细胞相互作用主要由LFA-1/ICAM-1途径介导。虽然ICAM-1在正常皮肤中的表皮角质形成细胞上不表达，但ICAM-1在炎性皮炎中由T细胞浸润部位的表皮角质形成细胞表达。ICAM-1在体内表达于胸腺上皮。这些抗原非依赖性粘附分子在与T细胞分化和功能相关的细胞-细胞相互作用中发挥重要作用。
Cell‐cell interaction is critical for normal T cell development and function. A number of adhesion molecules important in T cell interactions with other cell types have been defined. This paper reviews the role of two adhesion pathways, CD2/LFA‐3 and LFA‐1/ICAM‐1, in T cell interactions with epithelial cells of the thymus and skin. While thymic epithelium‐T cell interactions are mediated by both the LFA‐1/ICAM‐1 pathway and the CD2/LFA‐3 pathway, epidermal‐T cell interactions are mediated primarily by the LFA‐1/ICAM‐1 pathway. Although ICAM‐1 is not expressed in vivo on epidermal keratinocytes in normal skin, ICAM‐1 is expressed by epidermal keratinocytes at the site of T cell infiltration in inflammatory dermatitis. ICAM‐1 is expressed in vivo on thymic epithelium. These antigen independent adhesion molecules play an important role in the cell‐cell interactions associated with T cell differentiation and function.