INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY.
INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY.
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DOI：
10.1084/jem.58.5.607
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发表时间：
1933-10-31
期刊：
影响因子：
--
通讯作者：
Hurst EW
中科院分区：
文献类型：
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作者：
Shope RE;Hurst EW
在野生棉尾兔中观察到一种乳头状瘤，并发现其可传染给野生兔和家兔。的临床和病理图片的条件已被描述。已经发现，病原体很容易通过伯克菲尔德过滤器过滤，但不经常通过塞茨过滤器，它在甘油中储存良好，加热到67°C后仍然有活性。30分钟，但不是在加热至70°C后，并且它表现出对皮肤上皮的显著趋向性。产生乳头状瘤的因子的活性和性质保证其被分类为可过滤的病毒。携带实验产生的乳头状瘤的兔子对再感染部分或完全免疫，而且它们的血清部分或完全中和致病病毒。这种疾病可通过野兔连续传播，野兔来源的病毒很容易传播给家兔，在这种物种中产生的乳头状瘤与野兔中发现的乳头状瘤外观相同。然而，这种情况不会通过家兔连续传播。这一观察结果的可能意义已被讨论。传染性乳头状瘤病病毒与兔传染性纤维瘤病毒和兔传染性粘液瘤病毒在免疫学上均无相关性。
A papilloma has been observed in wild cottontail rabbits and has been found to be transmissible to both wild and domestic rabbits. The clinical and pathological pictures of the condition have been described. It has been found that the causative agent is readily filtrable through Berkefeld but not regularly through Seitz filters, that it stores well in glycerol, that it is still active after heating to 67°C. for 30 minutes, but not after heating to 70°C., and that it exhibits a marked tropism for cutaneous epithelium. The activities and properties of the papilloma-producing agent warrant its classification as a filtrable virus. Rabbits carrying experimentally produced papillomata are partially or completely immune to reinfection and, furthermore, their sera partially or completely neutralize the causative virus. The disease is transmissible in series through wild rabbits and virus of wild rabbit origin is readily transmissible to domestic rabbits, producing in this species papillomata identical in appearance with those found in wild rabbits. However, the condition is not transmissible in series through domestic rabbits. The possible significance of this observation has been discussed. The virus of infectious papillomatosis is not related immunologically to either the virus of infectious fibroma or to that of infectious myxoma of rabbits.