Integrin receptors in the glomerulus: potential role in glomerular injury.
Integrin receptors in the glomerulus: potential role in glomerular injury.
复制标题
肾小球整合素受体：在肾小球损伤中的潜在作用。
DOI：
10.1152/ajprenal.1992.262.5.f697
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Adler,S
中科院分区：
文献类型：
--
作者：
Adler,S
细胞外基质（ECM）对细胞功能发挥重要作用，在胚胎发生、伤口愈合、癌症转移和炎症等多种过程中发挥重要作用。细胞和基质之间的相互作用由ECM的不同组分的多种细胞表面受体介导。基质受体的整合素家族是迄今为止研究最多的一组，已经显示在其他系统中的细胞-基质和细胞-细胞相互作用中发挥重要作用。最近，已经确定了存在于肾小球和培养的肾小球细胞上的整合素受体的类型，并且已经假定它们可能参与肾小球损伤。本文将总结整合素受体的现有知识，其在肾脏中的分布，培养的肾小球细胞基质的相互作用，可能发挥作用，在调节肾小球细胞对损伤的反应，以及整合素和其他肾小球细胞基质受体的潜在作用作为目标的损伤蛋白尿病变。
The extracellular matrix (ECM) exerts important effects on cell function that play a vital role in such diverse processes as embryogenesis, wound healing, cancer metastasis, and inflammation. Interactions between cells and matrix are mediated by a variety of cell surface receptors for different components of the ECM. The integrin family of matrix receptors, the best-studied group thus far, has already been shown to play an important role in cell-matrix and cell-cell interactions in other systems. More recently, the types of integrin receptors present in the glomerulus and on cultured glomerular cells have been defined, and their potential involvement in glomerular injury has been postulated. This review will summarize current knowledge of integrin receptors, their distribution in the kidney, cultured glomerular cell-matrix interactions that might play a role in modulating the glomerular cell response to injury, and the potential role of integrins and other glomerular cell matrix receptors as targets of injury in proteinuric lesions.