Rheological characterization of novel carboxymethylated curdlan-silica hybrid hydrogels with tunable mechanical properties
Rheological characterization of novel carboxymethylated curdlan-silica hybrid hydrogels with tunable mechanical properties
复制标题
具有可调机械性能的新型羧甲基化凝胶多糖-二氧化硅杂化水凝胶的流变学表征
DOI：
10.1016/j.carbpol.2019.115578
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发表时间：
2020-02-15
影响因子：
11.2
通讯作者：
Zhang, Hongbin
中科院分区：
文献类型：
--
作者：
Cai, Zhixiang;Wu, Juan;Zhang, Hongbin
本工作涉及一种新型的杂化多糖-二氧化硅水凝胶的溶胶-凝胶过程中，一个完全水溶性的前体的四-（2-羟乙基）原硅酸盐（THEOS）和生物相容性多糖的羧甲基凝胶多糖（CMCD）已被使用。通过动态流变学、压缩试验和扫描电镜研究了不同浓度的CMCD和THEOS对杂化硅水凝胶动力学成胶过程、力学性能和形态结构的影响。发现CMCD在THEOS的水溶胶-凝胶过程中起到了催化剂和模板剂的作用。所得硅胶的机械强度可通过调节CMCD或THEOS的浓度来调节。较高含量的THEOS和CMCD导致较硬的凝胶。这些杂化水凝胶具有良好的力学性能和生物相容性，有望作为药物释放系统应用于生物医学领域。
The present work deals with a new type of hybrid polysaccharide-silica hydrogel fabricated by the sol-gel process in which a completely water-soluble precursor of tetrakis-(2-hydroxyethyl) orthosilicates (THEOS) and a bio-compatible polysaccharide of carboxymethylated curdlan (CMCD) have been used. The kinetic gelation process, mechanical properties and morphological structures of hybrid silica hydrogels at different concentrations of CMCD and THEOS were investigated by dynamic rheology, compression testing and scanning electron microscopy. CMCD was found to be served as a catalyst and template in the sol-gel process of THEOS in water. The mechanical strength of the resulting silica gels was tunable by the modulation of either the concentration of CMCD or THEOS. Higher content of THEOS and CMCD resulted in stiffer gels. Due to the tunable mechanical property and good biocompatibility, these hybrid hydrogels are promising for the applications as drug release systems in biomedical fields.