Prefrontal Cortex Represents Long-Term Memory of Object Values for Months
Prefrontal Cortex Represents Long-Term Memory of Object Values for Months
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DOI：
10.1016/j.cub.2018.05.017
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发表时间：
2018-07-23
期刊：
影响因子：
9.2
通讯作者：
Hikosaka, Okihide
中科院分区：
文献类型：
--
作者：
Ghazizadeh, Ali;Hong, Simon;Hikosaka, Okihide
作为认知控制的中枢，前额叶皮层（PFC）被认为是利用记忆的。然而，与工作记忆或短期记忆不同，PFC中长期记忆的神经元表征尚未得到系统的研究。利用猕猴的单单元记录，我们发现PFC神经元基于短期奖励历史快速更新和维持对物体的反应。有趣的是，在重复物体-奖励关联后，PFC神经元即使在没有奖励的情况下也会继续对物体表现出价值偏见反应。这种价值偏向反应在训练后保留了几个月，并且对许多复杂对象的新对象奖励学习的消失和干扰具有抵抗性（bbb90）。因此，猴子在几个月的单独测试中记住了学习过的物体的价值。这些发现表明，除了灵活的短期和低容量记忆外，灵长类动物的PFC还代表稳定的长期和高容量记忆，这些记忆可以优先考虑未来有价值的物体。
As a central hub for cognitive control, prefrontal cortex (PFC) is thought to utilize memories. However, unlike working or short-term memory, the neuronal representation of long-term memory in PFC has not been systematically investigated. Using single-unit recordings in macaques, we show that PFC neurons rapidly update and maintain responses to objects based on short-term reward history. Interestingly, after repeated object-reward association, PFC neurons continue to show value-biased responses to objects even in the absence of reward. This value-biased response is retained for several months after training and is resistant to extinction and to interference from new object-reward learning for many complex objects (>90). Accordingly, the monkeys remember the values of the learned objects for several months in separate testing. These findings reveal that in addition to flexible short-term and low-capacity memories, primate PFC represents stable long-term and high-capacity memories, which could prioritize valuable objects far into the future.