Are symptoms of depression more common in diabetes? Results from the Heinz Nixdorf Recall study
Are symptoms of depression more common in diabetes? Results from the Heinz Nixdorf Recall study
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DOI：
10.1111/j.1464-5491.2008.02585.x
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发表时间：
2008-11-01
影响因子：
3.5
通讯作者：
Moebus, S.
中科院分区：
文献类型：
--
作者：
Icks, A.;Kruse, J.;Moebus, S.
目的 在德国的大型人群样本中评估抑郁症状与 2 型糖尿病以及之前未发现的糖尿病之间的关联，并确定相关变量。方法我们使用德国 Heinz Nixdorf Recall 研究中 4595 名参与者（年龄 45-75 岁，50.2% 女性）的基线数据，这是一项始于 2000 年的基于人群的前瞻性队列研究。糖尿病通过自我报告进行评估（医生诊断或药物治疗），根据血糖水平未确诊的糖尿病。使用流行病学研究中心抑郁症 (CES-D) 简式量表（截止点 = 15 分）评估抑郁症状。我们拟合了多重逻辑回归模型。 结果 男性中诊断出的糖尿病和之前未发现的糖尿病患病率分别为 9.3%（95% 置信区间 8.2-11.6）和 7.6%（6.6-8.8），女性为 6.0%（5.1-7.1）和 3.2%（2.5-4.0）。与非糖尿病女性相比，糖尿病女性（年龄调整比值比，95% 置信区间 1.48；0.98-2.24）和未确诊糖尿病女性（0.67；0.33-1.36）的抑郁症状患病率没有显着差异。在男性中，糖尿病患者抑郁症状的患病率往往低于非糖尿病患者（0.62；0.35-1.09），但未确诊糖尿病的男性抑郁症状的发生率明显较低（0.30；0.13-0.70）。进一步调整后格局依然维持。研究发现，女性和男性的共病和无伴侣生活与抑郁症状显着相关，仅女性的体重指数和活动水平与抑郁症状显着相关。 结论 在调整相关协变量后，在我们的基于人群的研究中，抑郁症状与 2 型糖尿病之间的关联存在异质性。然而，在未确诊糖尿病的受试者中，男性的抑郁症状较少见。共病和心理社会状况与抑郁症状密切相关。
Aims To estimate the association between depressive symptoms and Type 2 diabetes, as well as previously undetected diabetes, in a large population-based sample in Germany and to determine associated variables.Methods We used baseline data on 4595 participants (age 45-75 years, 50.2% women) from the German Heinz Nixdorf Recall study, a population-based, prospective cohort study which started in 2000. Diabetes mellitus was assessed by self report (physician diagnosis or medication), undiagnosed diabetes based on blood glucose levels. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale short form (cut-off = 15 points). We fitted multiple logistic regression models.Results The prevalence of diagnosed and previously undetected diabetes was 9.3% (95% confidence interval 8.2-11.6) and 7.6% (6.6-8.8) in men and 6.0% (5.1-7.1) and 3.2% (2.5-4.0) in women, respectively. Compared with nondiabetic women, the prevalence of depressive symptoms was not significantly different in diabetic women (age-adjusted odds ratio, 95% confidence interval 1.48; 0.98-2.24) and women with undiagnosed diabetes (0.67; 0.33-1.36). In men, the prevalence of depressive symptoms tended to be lower in diabetic than in non-diabetic subjects ( 0.62; 0.35-1.09), but the depressive symptoms were significantly less frequent in men with undiagnosed diabetes (0.30; 0.13-0.70). The pattern remained after further adjustment. Significant associations with depressive symptoms were found for co-morbidities and living without a partner in both women and in men, and for body mass index and activity level in women only.Conclusions After adjustment for relevant covariates, the association between depressive symptoms and Type 2 diabetes was heterogenous in our population-based study. In subjects with undiagnosed diabetes, however, depressive symptoms were less frequent in men. Co-morbidities and psychosocial conditions are strongly associated with depressive symptoms.