Chorioretinitis induced by intravesical bacillus Calmette-Guerin (BCG) instillations for urinary bladder carcinoma
Chorioretinitis induced by intravesical bacillus Calmette-Guerin (BCG) instillations for urinary bladder carcinoma
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DOI：
10.1055/s-2003-38179
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发表时间：
2003-03-01
影响因子：
0.8
通讯作者：
Zografos, L
中科院分区：
文献类型：
--
作者：
Guex-Crosier, Y;Chamot, L;Zografos, L
背景：我们报告一个罕见的病例，在膀胱灌注卡介苗治疗原位癌后发生脉络膜视网膜炎。病史和体征：一名57岁男子因膀胱癌接受卡介苗滴注治疗。右眼视力为20/20，左眼视力为20/40。膀胱内卡介苗治疗开始后三个月发现双侧脉络膜视网膜炎。治疗和结果：用利福平、异烟肼和乙胺丁醇治疗6个月后，眼部病变没有进展。结论：卡介苗脉络膜视网膜炎是一种罕见的并发症，可以看到膀胱内卡介苗治疗后。BCG是牛分枝杆菌的减毒活菌株。两种机制可以被认为是眼部炎症的起源：局部免疫反应或直接脉络膜分枝杆菌感染。
Background: We report the rare case of a chorioretinitis occurring after intravesical BCG instillation to cure in situ carcinoma. History and signs: A 57-year old man was treated for bladder carcinoma with BCG instillations. Visual acuity was 20/20 in the right eye and 20/40 in the left eye. Bilateral chorioretinitis was discovered three months after initiation of intravesical BCG therapy. Therapy and outcome: No progression of ocular lesions could be seen after a 6 months therapy with rifampicin, isoniazide and ethambutol. Conclusions: BCG chorioretinitis is a rare complication that can be seen after intravesical BCG therapy. BCG is a live attenuated strain of Mycobacterium bovis. Two mechanisms can be proposed as the origin of ocular inflammation: a local immune response or a direct choroidal mycobacterial infection.