Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
复制标题
DOI：
10.1176/appi.ajp.160.5.883
复制
发表时间：
2003-05-01
影响因子：
17.7
通讯作者：
Post, RM
中科院分区：
文献类型：
--
作者：
Frye, MA;Altshuler, LL;Post, RM
目的：据报道，双相情感障碍患者终生酒精滥用和/或依赖（酒精中毒）的患病率高于所有其他轴I精神病诊断。本研究探讨性别之间的特定关系酗酒和双相情感障碍，以前很少收到系统的study.Method：终身酗酒的患病率在267名门诊病人参加斯坦利基金会双相网络进行了评估，通过使用结构化的临床访谈DSM-IV。酒精中毒和它的关系，以回顾性评估措施的过程中的双相情感障碍进行了评估，由患者评分和临床医生管理的questionnaire.Results：在一般人群中，更多的男性（49%，57 116）比女性双相情感障碍（29%，44 151）符合标准的终身酒精中毒。然而，与普通人群相比，双相情感障碍女性患者（比值比=7.35）酗酒的风险高于双相情感障碍男性患者（比值比=2.77）。酒精中毒与双相情感障碍的妇女和酗酒的家族史，在男性双相disorder.Conclusions：本研究表明，有性别差异的患病率，风险和酒精中毒的临床相关性在双相情感障碍的女性使用多种物质的历史。虽然这项研究受到疾病变量回顾性评估的限制，但这些性别特异性差异的程度是巨大的，需要进一步的前瞻性研究。
Objective: The prevalence of lifetime alcohol abuse and/or dependence (alcoholism) in patients with bipolar disorder has been reported to be higher than in all other axis I psychiatric diagnoses. This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study.Method: The prevalence of lifetime alcoholism in 267 outpatients enrolled in the Stanley Foundation Bipolar Network was evaluated by using the Structured Clinical Interview for DSM-IV. Alcoholism and its relationship to retrospectively assessed measures of the course of bipolar illness were evaluated by patient-rated and clinician-administered questionnaires.Results: As in the general population, more men (49%, 57 of 116) than women with bipolar disorder (29%, 44 of 151) met the criteria for lifetime alcoholism. However, the risk of having alcoholism was greater for women with bipolar disorder (odds ratio=7.35) than for men with bipolar disorder (odds ratio=2.77), compared with the general population. Alcoholism was associated with a history of polysubstance use in women with bipolar disorder and with a family history of alcoholism in men with bipolar disorder.Conclusions: This study suggests that there are gender differences in the prevalence, risk, and clinical correlates of alcoholism in bipolar illness. Although this study is limited by the retrospective assessment of illness variables, the magnitude of these gender-specific differences is substantial and warrants further prospective study.