Estimated premorbid intelligence mediates neurobehavioral change in individuals infected with HIV across 12 months
Estimated premorbid intelligence mediates neurobehavioral change in individuals infected with HIV across 12 months
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DOI：
10.1076/1380-3395(200004)22:2;1-1;ft208
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发表时间：
2000-01-01
影响因子：
2.2
通讯作者：
Bornstein, RA
中科院分区：
文献类型：
--
作者：
Basso, MR;Bornstein, RA
这项研究测试了估计的病前智力是否可以缓解 HIV 感染者神经行为功能障碍的恶化。对 155 名病情稳定的同性恋男性（54 名对照、49 名 HIV+ 无症状、24 名 HIV+ 有症状、28 名艾滋病）进行了基线执行功能测量和 12 个月随访测试。病前智力是根据人口统计回归方程估计的（Hamsher，1984），参与者被分类为平均或高于平均水平的智力。无论疾病状况如何，智商高于平均水平的参与者的执行功能指标并未随着时间的推移而下降。相比之下，在智商处于平均水平的人中，有症状的群体表现出下降，而无症状的群体则没有。研究结果支持这样的假设，即估计的病前智力介导了艾滋病毒状态稳定的患者神经心理功能的下降。这些发现与认知储备能力的理论模型一致。
This study tested whether estimated premorbid intelligence moderates worsening neurobehavioral dysfunction in HIV infection. 155 homosexual men (54 controls, 49 HIV+ asymptomatic, 24 HIV+ symptomatic, 28 AIDS) with stable disease status were tested on measures of executive function at baseline and 12-month follow-up. Premorbid intelligence was estimated on the basis of a demographically-based regression equation (Hamsher, 1984), and participants were classified as average or above-average intelligence. Regardless of disease status, participants with above-average IQ showed no declines on measures of executive function across time. In contrast, among those with average IQ, symptomatic groups showed declines, whereas the asymptomatic group did not. The findings support the hypothesis that estimated premorbid intelligence mediates declines in neuropsychological function in patients with stable HIV status. These findings are consistent with theoretical models of cognitive reserve capacity.