Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans
Oxytocin and vasopressin effects on the neural response to social cooperation are modulated by sex in humans
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DOI：
10.1007/s11682-014-9333-9
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发表时间：
2015-12-01
影响因子：
3.2
通讯作者：
Rilling, James K.
中科院分区：
文献类型：
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作者：
Feng, Chunliang;Hackett, Patrick D.;Rilling, James K.
最近的研究已经检查了催产素（OT）和加压素（AVP）对人类社会行为和脑功能的影响。然而，大多数参与者都是男性，而我们实验室以前的研究表明，OT和AVP对互惠合作的神经反应具有性别差异。在这里，我们通过显着增加参与者的数量来扩展我们以前的工作，以便使用更严格的统计阈值，从而可以更精确地定位大脑中的OT和AVP效应。在一项双盲、安慰剂对照研究中，153名男性和151名女性随机接受24 IU鼻内OT、20 IU鼻内AVP或安慰剂。之后，他们在与同性伴侣玩重复的囚徒困境游戏时接受功能性磁共振成像。性别差异观察到OT的神经反应的影响，以互惠合作，OT增加了男性之间的caduate/壳核反应，而它降低了女性之间的反应。因此，24 IU OT可能会增加男性积极社会互动的奖励或显着性，而降低女性的奖励或显着性。当采用更自由的统计阈值时，在双侧海马和右侧缘上回内也观察到AVP效应的类似性别差异。虽然我们的研究结果支持以前的建议，即外源性九肽可能是治疗抑郁症和自闭症谱系障碍等疾病的有效方法，但他们警告不要将这种治疗方法统一扩展到男性和女性。
Recent research has examined the effects of oxytocin (OT) and vasopressin (AVP) on human social behavior and brain function. However, most participants have been male, while previous research in our lab demonstrated sexually differentiated effects of OT and AVP on the neural response to reciprocated cooperation. Here we extend our previous work by significantly increasing the number of participants to enable the use of more stringent statistical thresholds that permit more precise localization of OT and AVP effects in the brain. In a double-blind, placebo-controlled study, 153 men and 151 women were randomized to receive 24 IU intranasal OT, 20 IU intranasal AVP or placebo. Afterwards, they were imaged with fMRI while playing an iterated Prisoner's Dilemma Game with same-sex partners. Sex differences were observed for effects of OT on the neural response to reciprocated cooperation, such that OT increased the caduate/putamen response among males, whereas it decreased this response among females. Thus, 24 IU OT may increase the reward or salience of positive social interactions among men, while decreasing their reward or salience among women. Similar sex differences were also observed for AVP effects within bilateral insula and right supramarginal gyrus when a more liberal statistical threshold was employed. While our findings support previous suggestions that exogenous nonapeptides may be effective treatments for disorders such as depression and autism spectrum disorder, they caution against uniformly extending such treatments to men and women alike.