Risk to human health from a plethora of Simian immunodeficiency viruses in primate bushmeat
Risk to human health from a plethora of Simian immunodeficiency viruses in primate bushmeat
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DOI：
10.3201/eid0805.010522
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发表时间：
2002-05-01
影响因子：
11.8
通讯作者：
Delaporte, E
中科院分区：
文献类型：
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作者：
Peeters, M;Courgnaud, V;Delaporte, E
为了评估非洲中西部人类对猿猴免疫缺陷病毒（SIV）的暴露，我们在788只在喀麦隆雨林中被猎杀的猴子中寻找SIV感染。在16种灵长类动物中的13种中发现了提示SIV感染的血清学反应，包括4种以前不知道的SIV携带者。总体而言，131份血清（16.6%）与HIV抗原反应强烈，另外34份（4.3%）与HIV抗原反应较弱。分子生物学分析确定了5个新的系统发育SIV谱系。这些数据首次证明，喀麦隆有相当大比例的野生猴子感染了SIV，狩猎和处理肉食的人类暴露于大量基因高度不同的病毒。
To assess human exposure to Simian immunodeficiency virus (SIV) in west central Africa, we looked for SIV infection in 788 monkeys that were hunted in the rainforests of Cameroon for bushmeat or kept as pets. Serologic reactivity suggesting SIV infection was found in 13 of 16 primate species, including 4 not previously known to harbor SIV. Overall, 131 sera (16.6%) reacted strongly and an additional 34 (4.3%) reacted weakly with HIV antigens. Molecular analysis identified five new phylogenetic SIV lineages. These data document for the first time that a substantial proportion of wild monkeys in Cameroon are SIV infected and that humans who hunt and handle bushmeat are exposed to a plethora of genetically highly divergent viruses.