Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses.
Comparative Cytogenetic Analysis of Spontaneous Abortions in Recurrent and Sporadic Pregnancy Losses.
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DOI：
10.1159/000446099
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Lebedev, Igor N
中科院分区：
文献类型：
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作者：
Nikitina, Tatiana V;Sazhenova, Elena A;Lebedev, Igor N
背景：大多数流产是偶发性的;然而，1-5%的夫妇经历过复发性流产（RPL）。大约50-60%的流产是由于染色体异常。目前，有相互矛盾的报告之间的复发性和散发性pregnancy loss.METHODS：442 RPL和466散发性流产（SA）的回顾性比较细胞遗传学分析。母亲的年龄和医疗背景进行了评估，染色体异常率进行了比较groups.Results：异常核型的胚胎的频率显着高于SA相比，RPL（56.7和46.6%，分别），和30岁以下的妇女流产是这种差异的主要贡献者。在两组女性中观察到异常核型率随年龄增长而增加-SA组[年轻组为53.0%，老年组为70.1（≥35岁）母亲，和无任何伴随生殖病理的特发性RPL患者（年轻母亲和年长母亲分别为46.5%和78.4%）-但在伴有生殖病理学的RPL女性组中并非如此。在随后的流产复发异常核型的发生率显着高于随机概率（比值比= 22.75）。结论：我们的研究结果突出了在复发性流产的非整倍体的风险的变化。
BACKGROUND: The majority of miscarriages are sporadic; however, 1-5% of couples experience recurrent pregnancy loss (RPL). Approximately 50-60% of miscarriages result from chromosomal abnormalities. Currently, there are conflicting reports regarding the rates of chromosomal abnormalities between recurrent and sporadic pregnancy losses.METHODS: A retrospective comparative cytogenetic analysis of 442 RPL and 466 sporadic abortions (SA) was performed. Maternal age and medical background were evaluated, and chromosomal abnormality rates were compared between groups.RESULTS: The frequency of embryos with abnormal karyotypes was significantly higher in SA compared to RPL (56.7 and 46.6%, respectively), and abortions from women under 30 years of age were the main contributor to this difference. An age-dependent increase in the abnormal karyotype rate was observed in two groups of women - those with SA [53.0 and 70.1% for younger and older (≥35-year-old) mothers, respectively] and those with idiopathic RPL without any concomitant reproductive pathology (46.5 and 78.4% for younger and older mothers) - but not in the group of women with RPL associated with concomitant reproductive pathology. The incidence of recurrent abnormal karyotypes in subsequent miscarriages was significantly higher than random probability (odds ratio = 22.75).CONCLUSION: Our findings highlight the variability in the risk of aneuploidy in recurrent abortion.