Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills
Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills
复制标题
利尿剂和减肥药致肾钙化假性Bartter综合征尸检报告
DOI：
10.1136/bcr.12.2008.1380
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发表时间：
2009
期刊：
影响因子：
0.9
通讯作者：
Ken
中科院分区：
文献类型：
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作者：
Kana Unuma;A. Tojo;K. Harada;Kanju Saka;M. Nakajima;T. Ishii;T. Fujita;Ken
一名四十多岁的女子在开始服用七种从泰国进口的减肥药后不久，出现反复呕吐和腹泻，并伴有肌肉无力。服药8天后，呼吸抑制迅速进展至停止。急诊室的血液检查显示严重的低钾血症伴代谢性贫血。根据离子异常、高肾素和醛固酮水平以及肾小球体增生的结果，我们诊断她患上了假性Bartter综合征。尸检血液分析表明呋塞米的含量低于治疗水平。我们的结论是，病人死于假性巴特综合征，这是由慢性自我管理速尿和减肥药加重。这是第一个伪巴特综合征尸检报告，显示组织学定位钙化的肾脏。
A woman in her mid-forties had repeated vomiting and diarrhoea accompanied by muscle weakness soon after she started taking seven different diet pills imported from Thailand. After she had taken the pills for 8 days, respiratory depression progressed rapidly to arrest. Blood tests at the Emergency Department showed severe hypokalaemia with metabolic alkalosis. We diagnosed that she had developed pseudo-Bartter syndrome from the findings based on ionic abnormalities and high renin and aldosterone levels, and hyperplasia of the juxtaglomerular apparatus. A postmortem blood analysis indicated subtherapeutic levels of furosemide. We concluded that the patient died from pseudo-Bartter syndrome, which was triggered by chronic self-administration of furosemide and aggravated by the diet pills. This is the first pseudo-Bartter syndrome autopsy report to show histological localisation of calcification in the kidneys.
佐藤隆：“调节酚氧化酶活性的新型有效肽”肽。
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