Plant Mitochondria are a Riddle Wrapped in a Mystery Inside an Enigma
Plant Mitochondria are a Riddle Wrapped in a Mystery Inside an Enigma
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DOI：
10.1007/s00239-020-09980-y
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发表时间：
2021-01-24
影响因子：
3.9
通讯作者：
Christensen, Alan C.
中科院分区：
文献类型：
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作者：
Christensen, Alan C.
植物线粒体基因组学研究的一个基本矛盾是：突变率很低（低于细胞核），但重排率很高。1988年发表在《分子进化杂志》上的一篇里程碑式的论文确立了这些事实，并揭示了这个悖论。杰弗里·帕尔默（Jeffrey Palmer）和劳拉·赫本（Laura Herbon）在基因组测序前的时代做了大量的工作，以确定密切相关物种之间的高频率重排和低频率突变，这些观察结果现在已经被测序多次证实。这篇论文也是第一次使用重排的分子数据作为系统发育特征来构建简约树。这项工作是一项技术上的杰作，其发现仍然是植物线粒体基因组学的核心，而产生这种悖论的潜在分子机制仍然没有完全理解。
A fundamental paradox motivates the study of plant mitochondrial genomics: the mutation rate is very low (lower than in the nucleus) but the rearrangement rate is high. A landmark paper published in Journal of Molecular Evolution in 1988 established these facts and revealed the paradox. Jeffrey Palmer and Laura Herbon did a prodigious amount of work in the pre-genome sequencing era to identify both the high frequency of rearrangements between closely related species, and the low frequency of mutations, observations that have now been confirmed many times by sequencing. This paper was also the first to use molecular data on rearrangements as a phylogenetic trait to build a parsimonious tree. The work was a technical tour-de-force, its findings are still at the heart of plant mitochondrial genomics, and the underlying molecular mechanisms that produce this paradox are still not completely understood.