Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women: a randomized, triple-blind, placebo-controlled trial
Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women: a randomized, triple-blind, placebo-controlled trial
复制标题
茴香磨的功效。
作者：
F. Rahimikian;R. Rahimi;Parvin Golzareh;R. Bekhradi;A. Mehran
目的：初步数据表明，茴香（茴香）可以是一种有效的治疗更年期症状。本试验旨在评估茴香在绝经后妇女绝经期症状管理中的疗效。方法：在这项三盲、安慰剂对照试验中，德黑兰90名年龄在45至60岁的绝经后妇女被随机分配到治疗组（n = 45）或安慰剂组（n = 45）。 参与者接受了8周的治疗，使用含有100 mg茴香或安慰剂的软胶囊（每组每天2粒）。 干预后对参与者进行2周的随访，以评估干预效果的持续性。使用绝经评定量表（MRS）问卷评估基线和干预开始后4、8和10周的绝经症状变化。结果：两组在干预前MRS问卷上的平均得分相似。干预后，治疗组的平均MRS评分显著降低。Friedman检验结果显示，治疗组基线时的平均评分与干预开始后4、8和10周的平均评分之间存在显著差异（P <0.001），而安慰剂组无显著差异。 当茴香组和安慰剂组进行比较时，独立t检验显示，在第4、8和10周（干预后2周; P <0.001），两组之间的平均得分存在显著差异。 结论：茴香是一种有效和安全的治疗，以减轻绝经后妇女的更年期症状，没有严重的副作用。需要更多的临床试验和更大的人群来证实这一结果。
Objective: Preliminary data suggest that Foeniculum vulgare (fennel) can be an effective treatment for menopausal symptoms. This trial was designed to assess the efficacy of fennel in the management of menopausal symptoms in postmenopausal women. Methods: In this triple-blind, placebo-controlled trial, 90 postmenopausal women aged 45 to 60 years in Tehran were randomly assigned to treatment (n = 45) or placebo (n = 45) groups. The participants received 8 weeks of treatment with soft capsules containing 100 mg fennel or a placebo (2 per day for each group). The participants were followed for 2 weeks postintervention to assess the continuance of the effect of intervention. The Menopause Rating Scale (MRS) questionnaire was used to assess changes in menopausal symptoms at baseline and at 4, 8, and 10 weeks after onset of intervention. Results: The groups recorded similar mean scores on the MRS questionnaire before intervention. After intervention, the treatment group showed a significant decrease in the mean MRS score. The results of the Friedman test showed significant differences between the mean score at baseline and those at 4, 8, and 10 weeks after onset of intervention in the treatment group (P < 0.001), whereas there were no significant differences in the placebo group. When the fennel and the placebo groups were compared, the independent t test showed significant differences in mean scores between groups at 4, 8, and 10 weeks (2 weeks postintervention; P < 0.001). Conclusions: Fennel is an effective and safe treatment to reduce menopausal symptoms in postmenopausal women without serious side effects. More clinical trials with larger populations are required to confirm this result.