Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.
Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans.
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由对结核分枝杆菌和软骨蛋白聚糖有反应的 T 淋巴细胞克隆诱导的关节炎。
DOI：
10.1073/pnas.82.15.5117
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发表时间：
1985
影响因子：
11.1
通讯作者：
Cohen,IR
中科院分区：
文献类型：
--
作者：
vanEden,W;Holoshitz,J;Nevo,Z;Frenkel,A;Klajman,A;Cohen,IR
以大鼠关节慢性炎症为特征的佐剂性关节炎是由结核分枝杆菌免疫诱导的。为了了解自身免疫性关节炎是如何由微生物抗原引起的，我们分离了一个对M。结核抗原是强致关节炎的。我们现在报告说，除了M。结核抗原、存在于人滑液中的抗原、软骨细胞培养物的培养基和从软骨纯化的蛋白聚糖。这些观察结果表明，致关节炎克隆的靶抗原存在于软骨的蛋白聚糖组分中。由于该致关节炎克隆对M.通过比较结核抗原和软骨成分，我们得出结论，疾病可能是由抗原交叉反应性引起的。因此，自身免疫性疾病可以由环境中的抗原与个体中的自身抗原之间的结构模拟触发。
Adjuvant arthritis characterized by chronic inflammation of the joints of rats is induced by immunization to Mycobacterium tuberculosis. To learn how autoimmune arthritis may be caused by a microbial antigen, we isolated a T-lymphocyte clone specific for M. tuberculosis antigens that was strongly arthritogenic. We now report that the clone recognized, in addition to M. tuberculosis antigens, antigens present in human synovial fluid, medium of chondrocyte cultures, and proteoglycans purified from cartilage. These observations indicate that the target antigen for the arthritogenic clone resides in the proteoglycan component of cartilage. As this arthritogenic clone shows specificity for both a M. tuberculosis antigen and a cartilage constituent we conclude that disease is probably caused by antigenic cross-reactivity. Thus, an autoimmune disease may be triggered by structural mimicry between antigens in the environment and self-antigens in the individual.