The cancer cell map initiative: defining the hallmark networks of cancer.
The cancer cell map initiative: defining the hallmark networks of cancer.
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DOI：
10.1016/j.molcel.2015.05.008
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发表时间：
2015-05-21
期刊：
影响因子：
16
通讯作者：
Ideker T
中科院分区：
文献类型：
--
作者：
Krogan NJ;Lippman S;Agard DA;Ashworth A;Ideker T
DNA测序的进展揭示了癌症基因组惊人的复杂性，通常携带数千个体细胞突变。然而，目前还不清楚在给定的癌症中，哪些是关键的驱动因素突变或相关性，以及这些突变是如何影响发病机制和治疗反应的。尽管类似类型和临床结果的肿瘤可能具有截然不同的突变模式，但越来越明显的是，这些突变反复劫持相同的标志性分子路径和网络。因此，癌症基因组的成功解释很可能需要对肿瘤发生中选择性压力下的分子网络的全面了解。在这里，我们宣布创建一项名为癌症细胞图谱倡议(CCMI)的新努力，旨在系统地详细说明癌症基因之间的这些复杂相互作用，以及它们在疾病和健康状态之间的区别。我们讨论了在一系列肿瘤类型中创建这些癌细胞地图的最新进展，以及如何使用它们来定位在个别患者中中断的网络，从而显著加快了精确医学的发展。
Progress in DNA sequencing has revealed the startling complexity of cancer genomes, which typically carry thousands of somatic mutations. However, it remains unclear which are the key driver mutations or dependencies in a given cancer and how these influence pathogenesis and response to therapy. Although tumors of similar types and clinical outcomes can have patterns of mutations that are strikingly different, it is becoming apparent that these mutations recurrently hijack the same hallmark molecular pathways and networks. For this reason, it is likely that successful interpretation of cancer genomes will require comprehensive knowledge of the molecular networks under selective pressure in oncogenesis. Here we announce the creation of a new effort, called The Cancer Cell Map Initiative (CCMI), aimed at systematically detailing these complex interactions among cancer genes and how they differ between diseased and healthy states. We discuss recent progress that enables creation of these Cancer Cell Maps across a range of tumor types and how they can be used to target networks disrupted in individual patients, significantly accelerating the development of precision medicine.