Effects of systemic and lateral semicircular canal administration of aminoglycosides on normal and hydropic inner ears.
Effects of systemic and lateral semicircular canal administration of aminoglycosides on normal and hydropic inner ears.
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DOI：
10.3109/00016489109100751
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发表时间：
1991
影响因子：
1.4
通讯作者：
Robert S. Kimura;Kwang-Sun Lee;Cynthia L. Nye;J. A. Trehey
中科院分区：
文献类型：
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作者：
Robert S. Kimura;Kwang-Sun Lee;Cynthia L. Nye;J. A. Trehey
12只单侧淋巴内积液的豚鼠皮下注射链霉素。在未手术的耳中，所有耳蜗基底端感觉细胞和前庭感觉器官都有不同程度的退化。相比之下，水耳对耳蜗和囊状感觉细胞表现出更大的耳毒性，而药物对脑室和嵴感觉细胞的作用增强，但不太显著。在另一组正常动物（n = 16）中，将链霉素应用于外侧半规管窗。三管嵴和室状黄斑的感觉细胞常发生变性，耳蜗的感觉细胞很少受影响。椎管入路引起的前庭病变大于全身注射引起的病变。与前庆大霉素-外侧管系列比较，两种药物的作用差异很小。然而，在水耳中，庆大霉素应用于侧耳管会增加所有感觉细胞的病变，特别是在Corti器官。耳部积水易受伤害，对于梅尼埃病患者，通过全身和管道途径给药氨基糖苷时需要更加谨慎。
Streptomycin was injected subcutaneously into guinea pigs (n = 12) with unilateral endolymphatic hydrops. In the unoperated ears, sensory cells were degenerated at the basal ends of all cochleas and to varying extents in the vestibular sense organs. Hydropic ears, in contrast, showed greater ototoxicity in the cochlear and saccular sensory cells, while the drug's effect on the utricular and cristae sensory cells was increased, but less remarkable. In another series of normal animals (n = 16), streptomycin was applied to a fenestra of the lateral semicircular canal. Sensory cells of all three canal cristae and utricular macula were degenerated frequently, but the sensory cells of the cochleas were rarely affected. The vestibular lesions resulting from the canal approach were greater than those produced by systemic injection. Comparison with a former gentamicin-lateral canal series revealed very little difference in action of the two drugs. However, in hydropic ears, gentamicin application to the lateral canal produced increased lesions in all sensory cells, particularly in the organ of Corti. Hydropic ears are vulnerable and a greater caution is needed in administering aminoglycosides by both the systemic and the canal route to patients with Meniere's disease.