Lifetime Exposure to Intimate Partner Violence and Proinflammatory Cytokine Levels Across the Perinatal Period
Lifetime Exposure to Intimate Partner Violence and Proinflammatory Cytokine Levels Across the Perinatal Period
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DOI：
10.1089/jwh.2015.5261
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发表时间：
2016-10-01
影响因子：
3.5
通讯作者：
O'Connor, Thomas G.
中科院分区：
文献类型：
--
作者：
Blackmore, Emma Robertson;Mittal, Mona;O'Connor, Thomas G.
背景：亲密伴侣暴力（IPV）是一个公共卫生问题，影响到三分之一的美国妇女。先前的研究表明，暴露于IPV和产妇围产期健康状况差之间的关联，但潜在的生物学相关性还没有得到很好的理解。本研究探讨了暴露于IPV和促炎细胞因子水平之间的关系，一个候选机制占整个围产期精神和产科预后不良。材料与方法：数据来自一项前瞻性、纵向队列研究，研究对象为171名接受产科护理的妇女，她们来自一家主要为低收入少数民族人口提供服务的医院。参与者完成了关于IPV暴露，精神症状，心理社会和产科因素的问卷调查，并在妊娠18周和32周以及产后6周和6个月提供了血液样本。采用酶联免疫吸附法测定血清白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）水平。结果如下：35名（20.5%）妇女报告终生暴露于IPV，7名（4.1%）妇女报告在过去12个月内受到身体伤害（4名在怀孕期间）。终生暴露于IPV与围产期抑郁症和怀孕期间吸烟的可能性增加有关。有IPV病史的女性在18周时TNF-α水平显著较高（z=-2.29，p
Background: Intimate partner violence (IPV) is a public health concern, affecting one-third of US women. Prior research suggests an association between exposure to IPV and poor maternal perinatal health, but the underlying biological correlates are not well understood. This study examined the relationship between exposure to IPV and proinflammatory cytokine levels, a candidate mechanism accounting for poor psychiatric and obstetric outcomes, across the perinatal period. Materials and Methods: Data were obtained from a prospective, longitudinal cohort study of 171 women receiving obstetrical care from a hospital-based practice serving a predominantly low-income minority population. Participants completed questionnaires on IPV exposure, psychiatric symptoms, and psychosocial and obstetric factors and provided blood samples at 18 and 32 weeks of gestation and 6 weeks and 6 months postpartum. Serum levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-) were assayed via enzyme-linked immunosorbent assay. Results: Thirty-five (20.5%) women reported lifetime exposure to IPV and 7 (4.1%) reported being physically hurt in the preceding 12 months (4 while pregnant). Lifetime exposure to IPV was associated with increased likelihood of experiencing perinatal depression and smoking during pregnancy. Women with a history of IPV had significantly higher levels of TNF- at 18 weeks (z=-2.29, p