Synthesis and evaluation of polyacrylamides derived from polycyclic pendant naphthalene, indole, and phenothiazine based chalcone moiety as potent antimicrobial agents
Synthesis and evaluation of polyacrylamides derived from polycyclic pendant naphthalene, indole, and phenothiazine based chalcone moiety as potent antimicrobial agents
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DOI：
10.1002/pat.3972
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发表时间：
2017-06-01
影响因子：
3.4
通讯作者：
Subramanian, Kathavarayan
中科院分区：
文献类型：
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作者：
Boopathy, Mani;Selvam, Ramasamy;Subramanian, Kathavarayan
含多环查耳酮的聚丙烯酰胺，即聚（（N-（4-（（E）-3-（萘-6-基）-3-氧代丙-1-烯基）苯基）丙烯酰胺），聚（（N-（4-（（E）-3-（1H-吲哚-3-基）-3-氧代丙-1-烯基）苯基）丙烯酰胺）和聚（N-（4-（（E）-3-氧代-3-（10 H-吩噻嗪-8-基）丙-1-烯基）苯基）丙烯酰胺）的合成。采用傅里叶变换红外光谱、H-1核磁共振和C-13核磁共振等技术对合成的聚合物进行了表征。用刃天青还原法对合成的聚丙烯酰胺进行了抗菌和抗真菌活性的筛选，结果表明，合成的聚丙烯酰胺对多种细菌和真菌具有良好的抗菌和抗真菌活性。在聚合物中，聚（（N-（4-（（E）-3-氧代-3-甲基苯基）氨基）-2-甲基-IH-吡唑-4-基）氨基）-IH-吡唑-4-甲酰胺（10 H-吩噻嗪-8-基）丙-1-烯基）苯基）丙烯酰胺）和聚（（N-（4-（（E）-3-（1H-吲哚-3-基）-3-氧代丙-1-烯基）苯基）丙烯酰胺）比聚具有更好的抗真菌和抗菌活性（（N-（4-（（E）-3-（萘-6-基）-3-氧代丙-1-烯基）苯基）丙烯酰胺），而所有聚合物均未显示出对粪链球菌和光滑念珠菌的抗细菌和抗真菌活性的任何迹象。版权所有（c）2016约翰威利父子有限公司
Polycyclic chalcone-containing polyacrylamides, namely, poly ((N-(4-((E)-3-(naphthalen-6-yl)-3-oxoprop-1-enyl) phenyl) acrylamide), poly((N-(4-((E)-3-(1H-indol-3-yl)-3-oxoprop-1-enyl) phenyl) acrylamide), and poly((N-(4-((E)-3-oxo-3-(10H-phenothiazin-8-yl) prop-1-enyl) phenyl) acrylamide), were synthesized by Claisen-Schmidt condensation reaction, followed by ultrasonic irradiation reduction. The synthesized polymers were characterized by Fourier transform infrared spectroscopy, H-1 nuclear magnetic resonance, and C-13 nuclear magnetic resonance spectroscopic technique. The newly synthesized polymers have been screened for antibacterial and antifungal activities by using resazurin reduction assay method, and the resulting polyacrylamides showed promising activity against various tested bacteria and fungi. Among the polymers, poly((N-(4-((E)-3-oxo-3-(10H-phenothiazin-8-yl) prop-1-enyl) phenyl) acrylamide) and poly((N-(4-((E)-3-(1H-indol-3-yl)-3-oxoprop-1-enyl) phenyl) acrylamide) exhibited better antifungal and antibacterial activities than poly ((N-(4-((E)-3-(naphthalen-6-yl)-3-oxoprop-1-enyl) phenyl) acrylamide), whereas all the polymers do not show any sign of antibacterial and antifungal activity against Streptococcus faecalis and Candida glabrata. Copyright (c) 2016 John Wiley & Sons, Ltd.