Prostate Cancer, Use of Androgen Deprivation Therapy, and Cognitive Impairment: A Population-based Study.
Prostate Cancer, Use of Androgen Deprivation Therapy, and Cognitive Impairment: A Population-based Study.
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前列腺癌、雄激素剥夺疗法的使用和认知障碍：一项基于人群的研究。
DOI：
10.1097/wad.0000000000000366
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发表时间：
2020
影响因子：
2.1
通讯作者：
Mielke,MichelleM
中科院分区：
文献类型：
--
作者：
AlonsoQuiñones,HectorJ;Stish,BradleyJ;Hagen,Clinton;Petersen,RonaldC;Mielke,MichelleM
方法：该研究纳入了2513名参加MCSA的男性（平均年龄73.1岁）。使用罗切斯特流行病学项目医疗记录链接系统提取前列腺癌病史、ADT使用情况和首次MCSA就诊前ADT暴露时间。在基线就诊时诊断为轻度认知障碍。使用逻辑回归来确定前列腺癌和ADT的使用是否与MCI的几率相关。结果：在2513名参与者中，349名（13.9%）有前列腺癌病史；其中99例（28.3%）在MCSA入组前接受过ADT治疗。382例（15.2%）诊断为轻度认知损伤。在单变量logistic回归模型中，前列腺癌（优势比为1.50,95%可信区间为1.12-2.00）和ADT暴露（优势比为1.57,95%可信区间为0.96-2.58）与MCI的高发生率相关。这些关联在多变量模型中被大大减弱且不显著。结论：在这项以人群为基础的横断面研究中，前列腺癌的诊断和ADT的使用都与MCI的发生率无关。
Methods:The study included 2513 men (mean age of 73.1 y) enrolled in the MCSA. A history of prostate cancer, ADT use, and length of ADT exposure before their first MCSA visit was abstracted using the Rochester Epidemiology Project medical records-linkage system. MCI was diagnosed at the baseline visit. Logistic regression was used to determine whether prostate cancer and ADT use was associated with odds of MCI.Results:Of the 2513 participants, 349 (13.9%) had a history of prostate cancer; among whom 99 (28.3%) were treated with ADT before MCSA enrollment. There were 382 (15.2%) with a diagnosis of MCI. In the univariate logistic regression models, prostate cancer (odds ratio, 1.50; 95% confidence interval, 1.12-2.00), and ADT exposure (odds ratio, 1.57; 95% confidence interval, 0.96-2.58) were associated with higher odds of MCI. These associations were greatly attenuated and not significant in multivariable models.Conclusions:Neither a diagnosis of prostate cancer nor ADT use was associated with odds of MCI in this cross-sectional population-based study.