NICTITATING-MEMBRANE CONDITIONING TO TONE IN IMMOBILIZED ALBINO RABBIT
NICTITATING-MEMBRANE CONDITIONING TO TONE IN IMMOBILIZED ALBINO RABBIT
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DOI：
10.1016/0006-8993(77)91016-2
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发表时间：
1977-01-01
期刊：
影响因子：
2.9
通讯作者：
LO, WD
中科院分区：
文献类型：
--
作者：
DISTERHOFT, JF;KWAN, HH;LO, WD
在头部固定、身体放松束缚的雄性白化病兔上，研究了瞬膜（NM）对音调起始条件反应（CR）的获得。条件刺激（CS）是在白色噪声背景上呈现的1000 Hz音调。非条件刺激（US）是指向暴露角膜的空气喷流。NM闭合用集成电路IR光反射传感器检测。非条件反应（UR）的潜伏期为17.5 ms，从喷烟开始在角膜。UR为双侧。所有22只实验兔在训练第I天均显示在对其进行抽吸的眼中获得CR。在第一天的最后40次试验中，组应答率接近80%。在第二和第三天，比率为90- 100%。平均CR反应潜伏期从第I天的177 ms显著降低至第II天的135 ms。9只假适应对照动物均未显示CR采集。以第10个CR的试验（而不是试验0）作为锚点构建学习曲线。当以这种方式进行检查时，CR发生概率在试验12和11之间（在锚点之前）突然增加了50%。在13只家兔中测定非抽吸眼（未接受空气抽吸US的眼）的NM性能。CR基本上是单方面的。当存在非抽吸CR时，它们的潜伏期显著长于抽吸眼中同时发生的CR，并且尺寸较小。作为一个系统，在其中检查学习的神经生理学和解剖学基板的兔NM空调的优势进行了讨论。
Acquisition of nictitating membrane (NM) conditioned responses (CRs) to tone onset was studied in male albino rabbits with their heads immobilized and bodies loosely restrained. The conditioned stimulus (CS) was a 1000 Hz tone presented over a white noise background. The unconditioned stimulus (US) was an air puff directed at the exposed cornea. NM closure was detected with an integrated circuit IR light reflection transducer. The latency of the unconditioned response (UR) was 17.5 ms from puff onset at the cornea. URs were bilateral. All 22 experimental rabbits showed CR acquisition in the eye to which puff was delivered on training day I. Group response rates approached 80% in the last 40 trials of day I. During days II and III, the rate was 90-100%. Mean CR response latency decreased significantly from 177 ms on day I-135 ms on day II. None of the 9 pseudoconditioning control animals showed CR acquisition. A learning curve was constructed with the trial of the 10th CR (rather than trial 0) as the anchor point. The probability of CR occurrence showed an abrupt 50% increase between trials 12 and 11 (before the anchor point) when examined in this fashion. NM performance of the non-puff eye (eye not receiving the air puff US) was determined in 13 rabbits. CRs were largely unilateral. When non-puff CRs were present, they were of significantly longer latency and of smaller size than those occurring simultaneously in the puff eye. The advantages of rabbit NM conditioning as a system in which to examine the neurophysiological and anatomical substrates of learning are discussed.