Effect of Qianliening Granule on Experimental Hyperplasia of Prostate
Effect of Qianliening Granule on Experimental Hyperplasia of Prostate
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发表时间：
2008
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通讯作者：
Lin Jiu-mao
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作者：
Lin Jiu-mao
目的研究前列宁对大鼠前列腺增生的影响。方法将120只SD大鼠随机分为空白组、模型组、前列宁颗粒不同剂量组、保列治对照组。睾丸切除后皮下注射丙酸睾丸酮4 mg/kg建立模型，同时用不同药物灌胃30 d。测定各组大鼠体重、前列腺重量、前列腺指数、前列腺形态学改变、血清睾酮（T）和雌二醇（E2）水平。结果模型组大鼠体重明显低于对照组（P0.05），前列腺重量和前列腺指数明显高于对照组（P0.01）。前列宁颗粒中、高剂量组前列腺重量和前列腺指数均显著降低（P0.01），前列宁颗粒高剂量组睾酮水平显著升高，雌二醇水平显著降低（P0.05）。结论前列宁能降低前列腺指数和湿重，调节T/E2比值，对前列腺增生大鼠有明显的量效关系。
Objective To study the effect of Qianliening on rats with benign prostatic hyperplasia. Methods 120 SD rats were divided randomly into blank group, model group, Baoliezhi control group and Qianliening granule groups with different doses. The models were established with hypodermic injection of testosterone propionate at 4 mg/kg after orchiectomy, at the same time, these rats were gastric perfused with different drugs respectively for 30 days. The body weight, prostate weight, prostate index, morphological changes, the level of T and E2 were measured. Results The body weight in model group was significantly lower than that in control group (P0.05), the prostate weight and index were obviously higher than that in control group (P0.01). The prostate weight and index were decreased significantly in Qianliening granule groups with meddle and high doses (P0.01), the level of testosterone was increased significantly and E2 was decreased obviously in Qianliening granule group with high doses. Conclusion Qianliening can decrease the prostate index and wet weight, and adjust the rate of T/E2, it shows an obvious dose-effect relationship on rats with benign prostatic hyperplasia.