Age-related hepatitis B seroconversion rates in health care workers
Age-related hepatitis B seroconversion rates in health care workers
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DOI：
10.1016/s0196-6553(97)90090-0
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发表时间：
1997-10-01
影响因子：
4.9
通讯作者：
Guss, P
中科院分区：
文献类型：
--
作者：
Havlichek, D;Rosenman, K;Guss, P
背景：据报道，在接受三次类adelid注射疫苗的健康成年人中，90%以上的人有保护性肝炎滴度。影响血清转化率的一些因素包括年龄、性别和慢性病的存在。方法：1986年至1993年间，112名年龄在20 ~ 70岁之间，平均年龄39.2岁的员工，由于工作相关因素使他们有感染乙型肝炎的危险，完成了乙型肝炎疫苗系列接种。所有参与者都接种了三次疫苗。结果：112名受者中有16名未出现乙型肝炎表面抗体（14.2%,95% CI， 7.6%至20.8%）。种族、性别和持续时间对抗体滴度没有影响血清转化率。与小于50岁的血清转换率（89.5%,95% CI 83.3% ~ 95.7%, p = 0.02）相比，年龄大于50岁的血清转换率显著降低（64.7%,95% CI 42.0% ~ 87.4%）。结论：我们的研究结果表明，在实施乙肝免疫规划后，健康成人和青少年的血清转换率低于公布的比率。我们建议对有乙型肝炎风险的员工免疫项目的血清转化数据进行审查，并考虑进行刺激后检测，以确保对不转化风险最高的员工提供充分的保护。
Background: Protective hepatitis titers are reported for more than 90% of healthy adults who received three intradeltoid injections of vaccine. Some factors that influence seroconversion rates include age, sex, and presence of chronic diseases.Methods: Because of work-related factors that placed them at risk of acquiring hepatitis B, 112 employees, who ranged in age from 20 to 70 years with a mean age of 39.2 years, completed the hepatitis B vaccination series between 1986 and 1993. All participants received three vaccinations.Results: Hepatitis B surface antibody did not develop in 16 of 112 recipients (14.2%, 95% CI, 7.6% to 20.8%). Race, sex, and duration to antibody titer did not affect rates of seroconversion. Age greater than 50 years was associated with significantly decreased seroconversion rates (64.7%, 95% CI, 42.0% to 87.4%) compared with seroconversion rates of those younger than 50 years of age (89.5%, 95% CI 83.3% to 95.7%, p = 0.02).Conclusions: Our results indicate that it-hen a hepatitis B immunization program is implemented, seroconversion rates are lower than published rates for healthy adults and adolescents. We recommend that seroconversion data from immunization programs for employees at risk for hepatitis B be reviewed and that postimmunization testing be considered to ensure adequate protection for those employees at highest risk for nonconversion.