Two Faces of Neutrophils in Liver Disease Development and Progression.
Two Faces of Neutrophils in Liver Disease Development and Progression.
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DOI：
10.1002/hep.31680
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发表时间：
2021-07
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中性粒细胞是人类血液中最丰富的白细胞类型，在宿主防御入侵病原体和无菌性损伤中起主要作用。由于其抗菌和细胞毒性活性，神经浸润是炎症的特征。中性粒细胞还通过充当炎症和组织损伤的消退阶段之间的关键介质而积极参与炎症的消退和随后的组织修复。然而，持续暴露于炎性病症的中性粒细胞失去其自我解决能力并维持炎性表型，从而进一步加剧组织损伤。本文综述了中性粒细胞如何与组织微环境相互作用，并在慢性炎症条件下获得疾病特异性表型。在这里，我们的目的是提供一个更好的了解嗜中性粒细胞介导的各种肝脏疾病的发病机制。
Neutrophils, the most abundant type of leukocyte in human blood, play a major role in host defense against invading pathogens and in sterile injury. Neutrophil infiltration is characteristic of inflammation because of its antimicrobial and cytotoxic activities. Neutrophils also actively participate in the resolution of inflammation and subsequent tissue repair by acting as a critical mediator between the inflammation and resolution phases of tissue damage. However, neutrophils that are consistently exposed to inflammatory conditions lose their self-resolving capabilities and maintain an inflammatory phenotype, further exacerbating tissue damage. The current review describes how neutrophils interact with tissue microenvironments and acquire disease-specific phenotypes under chronic inflammatory conditions. Here, we aim to provide a better understanding of neutrophil-mediated pathogenesis of various liver diseases.