Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus
Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus
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DOI：
10.1016/j.fgb.2010.12.006
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发表时间：
2011-04-01
影响因子：
3
通讯作者：
Turner, Geoffrey
中科院分区：
文献类型：
--
作者：
Allen, Gethin;Bromley, Mike;Turner, Geoffrey
条件致病菌烟曲霉的线粒体磷脂酰基转移酶基因pptB已被鉴定和鉴定。与PPTA不同，PPTA是赖氨酸生物合成、次生代谢和铁同化所必需的，PPTB是生存所必需的。PptB位于线粒体内。PPTA和pptB的体外表达表明，PptB是线粒体酰基载体蛋白ACPA的特异性蛋白。(C)2010 Elsevier Inc.保留所有权利。
The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA. (c) 2010 Elsevier Inc. All rights reserved.