SOMATOSENSORY EVENT-RELATED POTENTIALS TO PAINFUL AND NON-PAINFUL STIMULI - EFFECTS OF ATTENTION

SOMATOSENSORY EVENT-RELATED POTENTIALS TO PAINFUL AND NON-PAINFUL STIMULI - EFFECTS OF ATTENTION
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DOI：
10.1016/0304-3959(89)90217-0
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发表时间：
1989-09-01
期刊：
PAIN
影响因子：
7.4
通讯作者：
LARBIG, W
LARBIG, W
中科院分区：
医学1区
文献类型：
--
作者：
MILTNER, W;JOHNSON, R;LARBIG, W

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为探讨注意和分心对疼痛和非疼痛刺激的影响，研究了疼痛和非疼痛电刺激诱发的体感事件相关电位（SERP）3个成分（N150、P200、P300）的幅度变化。使用视觉模拟量表确定疼痛和非疼痛刺激。从16名健康志愿者的5个中线和4个左右半球的网站记录SERP。注意和忽略刺激的幅度之间的差异进行了量化与基线到峰值的措施。方差分析结果显示，没有显着的注意或刺激强度的影响N150，但高度显着的差异，在P200和P300振幅之间的关注和忽视的刺激。此外，P200和P300的幅度更大的强刺激比弱刺激，无痛苦和痛苦的刺激之间没有显着差异。这些发现与SERP分量振幅和主观疼痛报告之间存在相对关系而非绝对关系相一致。此外，数据提供的证据表明，注意力操纵代表了一个强大的方法，以减少疼痛的感知，当使用主观和行为的措施，SERP代表了一个宝贵的资产，在多维方法疼痛测量和评估。
In order to determine the effects of attention and distraction on painful and non-painful stimuli, the amplitude changes of 3 components (N150, P200, P300) of the somatosensory event-related potential (SERP) elicited by painful and non-painful electrical stimuli were investigated. Painful and non-painful stimuli were determined using a visual analog scale. SERPs were recorded from 16 healthy volunteers at 5 midline and 4 left and 4 right hemispheric sites. The differences between the amplitudes of attended and ignored stimuli were quantified with a baseline-to-peak measure. ANOVA results revealed no significant attention or stimulus intensity effects for N150 but highly significant differences in P200 and P300 amplitudies between attended and ignored stimuli. In addition, P200 and P300 amplitudes were larger for strong stimuli than for weak stimuli, with no significant differences between non-painful and painful stimuli. These findings are consistent with the existence of a relative, rather than an absolute, relationship between SERP component amplitudes and subjective pain reports. Furthermore, the data give evidence that attentional manipulations represent a powerful method to decrease the perception of pain and that, when used with subjective and behavioral measures, the SERP represents a valuable asset in the multidimensional approach to pain measurement and assessment.