Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice
Tyrosol Ameliorates the Symptoms of Obesity, Promotes Adipose Thermogenesis, and Modulates the Composition of Gut Microbiota in HFD Fed Mice
复制标题
酪醇可改善 HFD 喂养小鼠的肥胖症状、促进脂肪产热并调节肠道微生物群的组成
DOI：
10.1002/mnfr.202101015
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发表时间：
2022-05-18
影响因子：
5.2
通讯作者：
Luo, Ting
中科院分区：
文献类型：
--
作者：
Li, Xiaoping;Wei, Teng;Luo, Ting
范围酪醇是特级初榨橄榄油（EVOO）中的主要多酚化合物之一，其在对抗肥胖方面的作用尚不清楚。因此，本研究旨在研究酪醇消耗对高脂饮食（HFD）诱导的小鼠肥胖的影响及其潜在机制。方法和结果补充0.2%（wt/wt）酪醇16周后，与HFD组相比，最终体重、血浆三酰甘油（TG）、总胆固醇（TC）和空腹血糖水平显著降低。此外，酪醇可作为与核激素受体过氧化物酶体增殖物激活受体α（PPAR α）结合的配体。酪醇给药后，棕色脂肪组织（BAT）和腹股沟白色脂肪组织（iWAT）中解偶联蛋白1（UCP 1）、碘甲腺原氨酸脱碘酶2（DIO 2）、PPAR-γ共激活因子-1 α（PGC-1 α）和含PR结构域16（PRDM 16）（与脂肪细胞产热功能相关的PPAR α下游基因）均显著增加。此外，酪醇改变了肠道微生物群的群落组成，包括降低厚壁菌门与拟杆菌门的比例，并增加了鼠杆菌科、布劳特氏菌属和毛螺菌科_bacterium_28_4的相对丰度。结论酪醇消耗可能通过调节PPAR α产热和肠道菌群来减轻HFD喂养小鼠的肥胖和相关症状。
Scope Tyrosol is one of the main polyphenolic compounds in extra virgin olive oil (EVOO) and its role in combating obesity is unknown. Thus, this study is designed to investigate the effect of tyrosol consumption on obesity and its underlying mechanisms in high-fat diet (HFD)-induced mice. Methods and results After supplementation with 0.2% (wt/wt) tyrosol for 16 weeks, the final body weight, and the levels of plasma triacylglycerol (TG), total cholesterol (TC), and fasting glucose are significantly decreased when compared with HFD group. Furthermore, tyrosol may act as a ligand which binds with nuclear hormone receptor peroxisome proliferator-activated receptor alpha (PPAR alpha). Uncoupling protein 1 (UCP1), iodothyronine deiodinase 2 (DIO2), PPAR-gamma coactivator-1 alpha (PGC-1 alpha), and PR domain containing 16 (PRDM16), the downstream genes of PPAR alpha which are related to thermogenic function of adipocytes, are significantly increased in both brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) after tyrosol administration. In addition, tyrosol changes the community composition of gut microbiota, including decreasing the ratio of Firmicutes to Bacteroidetes, and increasing the relative abundance of family muribaculaceae, genus Blautia and Lachnospiraceae_bacterium_28_4. Conclusion Tyrosol consumption attenuates obesity and related symptoms in HFD-fed mice probably via the modulation of PPAR alpha-thermogenesis and gut microbiota.