Platelet to lymphocyte ratio as a novel indicator of inflammation is correlated with the severity of metabolic syndrome: A single center large-scale study
Platelet to lymphocyte ratio as a novel indicator of inflammation is correlated with the severity of metabolic syndrome: A single center large-scale study
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DOI：
10.3109/09537104.2015.1064518
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发表时间：
2016-02-17
期刊：
影响因子：
3.3
通讯作者：
Aras, Dursun
中科院分区：
文献类型：
--
作者：
Akboga, Mehmet Kadri;Canpolat, Ugur;Aras, Dursun
代谢综合征（MetS）是一组由多种心血管代谢成分组成的疾病，是全球范围内日益严重的公共卫生问题，与心血管疾病的预后密切相关。内脏脂肪增多激活了连接低度慢性炎症、氧化应激和血液凝固的重要途径。最近，血小板与淋巴细胞比率（PLR）已被证明是一种新的间接炎症标志物。因此，我们首次旨在研究PLR与MetS的存在和严重程度的相关性。在这项横断面研究中，共招募了1146名参与者（n=539名患有MetS，n=607名未患有MetS）。MetS根据NCEP-ATP III标准定义。MetS（+）组PLR和C-反应蛋白（CRP）水平显著高于MetS（-）组（p
Metabolic syndrome (MetS) as a cluster of several cardio-metabolic components is rapidly growing public-health problem worldwide and significantly associated with poor cardiovascular outcomes. Increased visceral adiposity activates the important pathways connecting low-grade chronic inflammation, oxidative stress and blood coagulation. Recently, platelet to lymphocyte ratio (PLR) has been evidenced as a novel indirect inflammatory marker. Therefore, for the first time, we aimed to investigate the association of PLR with both the presence and severity of MetS. In this cross-sectional study, a total of 1146 participants were enrolled (n=539 with MetS and n=607 without MetS). MetS was defined according to NCEP-ATP III criteria. MetS (+) group revealed significantly higher PLR and C-reactive protein (CRP) levels as compared to MetS (-) group (p