Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine.
Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine.
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DOI：
10.1016/j.neuroscience.2010.12.008
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发表时间：
2011-03-10
期刊：
影响因子：
3.3
通讯作者：
Xu, M.
中科院分区：
文献类型：
--
作者：
Kong, H.;Kuang, W.;Li, S.;Xu, M.
Memories of learned associations between the rewarding properties of drugs and environmental cues contribute to craving and relapse in humans. The mesocorticolimbic dopamine (DA) system is involved in reward-related learning induced by drugs of abuse. DA D3 receptors are preferentially expressed in mesocorticolimbic DA projection areas. Genetic and pharmacological studies have shown that DA D3 receptors suppress locomotor-stimulant effects of cocaine and reinstatement of cocaine-seeking behaviors. Activation of the extracellular signal-regulated kinase (ERK) induced by acute cocaine administration is also inhibited by D3 receptors. How D3 receptors modulate cocaine-induced reward-related learning and associated changes in cell signaling in reward circuits in the brain, however, have not been fully investigated. In the present study, we show that D3 receptor mutant mice exhibit potentiated acquisition of conditioned place preference (CPP) at low doses of cocaine compared to wild-type mice. Activation of ERK and Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα), but not the c-Jun N-terminal kinase and p38, in the nucleus accumbens, amygdala and prefrontal cortex is also potentiated in D3 receptor mutant mice compared to that in wild-type mice following CPP expression. These results support a model in which D3 receptors modulate reward-related learning induced by low doses of cocaine by inhibiting activation of ERK and CaMKIIα in reward circuits in the brain.
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影响因子：
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作者：
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影响因子：
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发表时间：
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影响因子：
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