Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
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DOI：
10.1101/gad.1839209
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发表时间：
2009-12-15
影响因子：
10.5
通讯作者：
Guarente, Leonard P.
中科院分区：
文献类型：
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作者：
Cohen, Dena E.;Supinski, Andrea M.;Guarente, Leonard P.
哺乳动物的寿命可以通过热量限制（CR）和减少生长激素信号的突变来延长。Sirt1在哺乳动物中是CR的许多效应的介导者，但在控制促生长信号传导中的任何作用尚未显示。由于促生长轴是由大脑控制的，我们创造了大脑中缺乏Sirt1的小鼠，并检查了这种操作对促生长信号传导和CR反应的影响。这些突变小鼠显示缺陷的生长激素信号时，随意喂养，并在CR的内分泌和行为反应的缺陷。我们的结论是，Sirt1在大脑中是一个联系体细胞信号和CR在哺乳动物。
Mammalian life span can be extended by both calorie restriction (CR) and mutations that diminish somatotropic signaling. Sirt1 is a mediator of many effects of CR in mammals, but any role in controlling somatotropic signaling has not been shown. Since the somatotropic axis is controlled by the brain, we created mice lacking Sirt1 specifically in the brain and examined the impacts of this manipulation on somatotropic signaling and the CR response. These mutant mice displayed defects in somatotropic signaling when fed ad libitum, and defects in the endocrine and behavioral responses to CR. We conclude that Sirt1 in the brain is a link between somatotropic signaling and CR in mammals.