Interactions of prolactin and adrenocorticotropin in the regulation of adrenocortical secretions in female rats.
Interactions of prolactin and adrenocorticotropin in the regulation of adrenocortical secretions in female rats.
复制标题
催乳素和促肾上腺皮质激素在雌性大鼠肾上腺皮质分泌调节中的相互作用。
DOI：
10.1210/endo-104-1-40
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发表时间：
1979
期刊：
影响因子：
4.8
通讯作者：
J. I. Kitay
中科院分区：
文献类型：
--
作者：
T. Ogle;J. I. Kitay
本实验观察了催乳素和促肾上腺皮质激素单独及联合应用对去垂体雌性大鼠肾上腺功能的影响。体内研究包括测量外周血浆和左肾上腺静脉流出物中的激素浓度。计算皮质酮及其主要还原代谢产物5-α-二氢皮质酮和3-β，5-α-四氢皮质酮的分泌速率。本文研究了大鼠肾上腺组织匀浆和肾上腺切片中5-α-还原酶的活性及皮质酮和总皮质激素的产生。摘除垂体后肾上腺5-α-还原酶活性升高。结果，皮质酮迅速转化为DHB和THB。去垂体大鼠注射催乳素后，肾上腺5-α-还原酶活性降低，肾上腺流出液皮质酮分泌量增加79%。外周血浆皮质酮浓度也同样升高。与皮质酮相关的分泌。
Effects of PRL and ACTH alone and in combination upon adrenal function of hypophysectomized female rats were examined in vivo and in vitro. In vivo studies consisted of measuring hormone concentrations in peripheral plasma and in the venous effluent of the left adrenal gland. Secretion rates of corticosterone and its principal reduced metabolites [5α-dihydrocorticosterone (DHB) and 3β,5α-tetrahydrocorticosterone (THB)] were calculated. Adrenal 5α-reductase activity and production of corticosterone and total corticoids by adrenal homogenates and adrenal slices were studied in vitro. Removal of the pituitary elevated adrenal 5α-reductase activity. As a result, corticosterone was rapidly converted to DHB and THB. Administration of PRL to hypophysectomized rats resulted in decreased adrenal 5α-reductase activity and concomitantly increased the secretion of corticosterone in adrenal effluent by 79%. The peripheral plasma concentration of corticosterone was enhanced similarly. Secretion of corticosterone relati...